BAYK 8644

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531565

CAS#: 71145-03-4

Description: BAYK 8644 is a L-type Ca2+ channel activator (EC50 = 17.3 nM). BAYK 8644 has positive inotropic, vasoconstrictive and behavioral effects in vivo.


Price and Availability

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BAYK 8644 , is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531565
Name: BAYK 8644
CAS#: 71145-03-4
Chemical Formula: C16H15F3N2O4
Exact Mass: 356.0984
Molecular Weight: 356.3
Elemental Analysis: C, 53.94; H, 4.24; F, 16.00; N, 7.86; O, 17.96


Synonym: BAYK 8644; BAYK8644; BAYK-8644.

IUPAC/Chemical Name: methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

InChi Key: ZFLWDHHVRRZMEI-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3

SMILES Code: O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR. Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. Chin J Physiol. 2013 Dec 31;56(6):318-25. doi: 10.4077/CJP.2013.BAB161. Erratum in: Chin J Physiol. 2014 Feb 28;57(1):60. PubMed PMID: 24495178.

2: Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. J Biol Chem. 2010 Mar 5;285(10):6996-7005. doi: 10.1074/jbc.M109.059865. PubMed PMID: 20054004; PubMed Central PMCID: PMC2844149.

3: Turner CP, Debenedetto D, Liu C. NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644. Neurosci Lett. 2009 Feb 6;450(3):292-5. doi: 10.1016/j.neulet.2008.12.002. PubMed PMID: 19070650; PubMed Central PMCID: PMC2699449.

4: Kuzmenkin A, Hang C, Kuzmenkina E, Jurkat-Rott K. Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644. Pflugers Arch. 2007 Jul;454(4):605-14. PubMed PMID: 17333247.

5: Artigas P, Ferreira G, Reyes N, Brum G, Pizarro G. Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. J Membr Biol. 2003 Jun 1;193(3):215-27. PubMed PMID: 12962282.

6: Katoh H, Schlotthauer K, Bers DM. Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. Circ Res. 2000 Jul 21;87(2):106-11. PubMed PMID: 10903993.

7: Satoh H, Hayashi H, Blatter LA, Bers DM. BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes. Heart Vessels. 1997;Suppl 12:58-61. PubMed PMID: 9476545.

8: Tusell JM, Barron S, Serratosa J. Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Neurotoxicology. 1994 Fall;15(3):751-6. PubMed PMID: 7531829.

9: Bartrup JT, Stone TW. Inhibition of adenosine responses of rat hippocampal neurones by nifedipine and BAYK 8644. Brain Res. 1990 Aug 20;525(2):315-8. PubMed PMID: 1701332.

10: Yu C, Jia M, Litzinger M, Nelson PG. Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons. Exp Brain Res. 1988;71(3):467-74. PubMed PMID: 2458275.

11: Fredholm BB, Hu PS, Lindgren E. The dihydropyridine calcium-channel agonist BayK 8644 inhibits the presynaptic effects of R-phenylisopropyl adenosine in the rat hippocampus. Acta Physiol Scand. 1986 Dec;128(4):659-60. PubMed PMID: 2433900.