BAY 60-6583

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531563

CAS#: 910487-58-0

Description: BAY 60-6583 is a selective and potent agonist of adenosine A2B receptor with EC50 value of 3 nM. The adenosine A2B receptor plays an important role in anti-inflammatory response and pre/postconditioning cardioprotective.


Price and Availability

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BAY 60-6583, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531563
Name: BAY 60-6583
CAS#: 910487-58-0
Chemical Formula: C19H17N5O2S
Exact Mass: 379.1103
Molecular Weight: 379.44
Elemental Analysis: C, 60.14; H, 4.52; N, 18.46; O, 8.43; S, 8.45


Synonym: BAY 60-6583; BAY-60-6583; BAY60-6583.

IUPAC/Chemical Name: 2-({6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide

InChi Key: ZTYHZMAZUWOXNC-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)

SMILES Code: O=C(N)CSC1=NC(N)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hayashi M, Inagaki A, Novak I, Matsuda H. The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells. Pflugers Arch. 2016 Jul;468(7):1171-81. doi: 10.1007/s00424-016-1806-9. PubMed PMID: 26965147; PubMed Central PMCID: PMC4943985.

2: Wen J, Wang B, Du C, Xu G, Zhang Z, Li Y, Zhang N. A2B Adenosine Receptor Agonist Improves Erectile Function in Diabetic Rats. Tohoku J Exp Med. 2015;237(2):141-8. doi: 10.1620/tjem.237.141. PubMed PMID: 26447087.

3: Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. PubMed PMID: 26385692; PubMed Central PMCID: PMC4648794.

4: Sorrentino C, Miele L, Porta A, Pinto A, Morello S. Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model. Oncotarget. 2015 Sep 29;6(29):27478-89. doi: 10.18632/oncotarget.4393. PubMed PMID: 26317647; PubMed Central PMCID: PMC4695003.