Kakonein
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529717

CAS#: 3681-99-0

Description: Kakonein, also known as Puerarin, is an L-type calcium channel blocker potentially for the treatment of alcoholism.


Price and Availability

Size
Price

200mg
USD 240
Size
Price

1g
USD 530
Size
Price

Kakonein, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 529717
Name: Kakonein
CAS#: 3681-99-0
Chemical Formula: C21H20O9
Exact Mass: 416.1107
Molecular Weight: 416.38
Elemental Analysis: C, 60.58; H, 4.84; O, 34.58


Synonym: NPI-031G; NPI031G; NPI 031G; Puerarin

IUPAC/Chemical Name: 7-hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one

InChi Key: HKEAFJYKMMKDOR-VPRICQMDSA-N

InChi Code: InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

SMILES Code: O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC=C13


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhao YZ, Zhang L, Gupta PK, Tian FR, Mao KL, Qiu KY, Yang W, Lv CZ, Lu CT. Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease. AAPS PharmSciTech. 2016 Dec;17(6):1376-1382. PubMed PMID: 26753818.

2: Liu X, Mo Y, Gong J, Li Z, Peng H, Chen J, Wang Q, Ke Z, Xie J. Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Metab Brain Dis. 2016 Apr;31(2):417-23. doi: 10.1007/s11011-015-9779-5. PubMed PMID: 26686502.

3: Liu CM, Ma JQ, Liu SS, Feng ZJ, Wang AM. Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. Chem Biol Interact. 2016 Jan 5;243:29-34. doi: 10.1016/j.cbi.2015.11.017. PubMed PMID: 26607348.

4: Li R, Song J, Wu W, Wu X, Su M. Puerarin exerts the protective effect against chemical induced dysmetabolism in rats. Gene. 2016 Dec 31;595(2):168-174. doi: 10.1016/j.gene.2016.09.036. PubMed PMID: 27677221.

5: Zhao J, Cheng Y, Yang C, Lau S, Lao L, Shuai B, Cai J, Rong J. Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. Mol Neurobiol. 2016 May;53(4):2200-11. doi: 10.1007/s12035-015-9195-1. PubMed PMID: 25952544.

6: Zhang F, Wang Z, Li M, Lan Y, Chen Y, Wang C. Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats. Int Immunopharmacol. 2015 Sep;28(1):546-53. doi: 10.1016/j.intimp.2015.07.023. PubMed PMID: 26218281.

7: Liu S, Ren HB, Chen XL, Wang F, Wang RS, Zhou B, Wang C, Sun YX, Wang YJ. Puerarin attenuates severe burn-induced acute myocardial injury in rats. Burns. 2015 Dec;41(8):1748-57. doi: 10.1016/j.burns.2015.06.001. PubMed PMID: 26514700.

8: Yang X, Zhang H, Wang J, Zhang Z, Li C. Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis. J Periodontal Res. 2015 Dec;50(6):748-57. doi: 10.1111/jre.12261. PubMed PMID: 25645818.

9: Zhang J, Guo W, Tian B, Sun M, Li H, Zhou L, Liu X. Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia. Int J Clin Exp Pathol. 2015 May 1;8(5):4695-704. PubMed PMID: 26191159; PubMed Central PMCID: PMC4503031.

10: Zhang Y, Wang H, Yu L, Chen J. The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. Ren Fail. 2015 May;37(4):699-703. doi: 10.3109/0886022X.2015.1011500. PubMed PMID: 25707518.

11: Ma Y, Gai Y, Yan J, Li J, Zhang Y. Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy. Med Sci Monit. 2016 Mar 24;22:977-83. PubMed PMID: 27011313; PubMed Central PMCID: PMC4809386.

12: Yang L, Yao D, Yang H, Wei Y, Peng Y, Ding Y, Shu L. Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling. Mol Endocrinol. 2016 Mar;30(3):361-71. doi: 10.1210/me.2015-1213. PubMed PMID: 26789107.

13: Liu B, Wu Z, Li Y, Ou C, Huang Z, Zhang J, Liu P, Luo C, Chen M. Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. Biochem Biophys Res Commun. 2015 Aug 28;464(3):908-15. doi: 10.1016/j.bbrc.2015.07.065. PubMed PMID: 26188094.

14: Liu B, Tan Y, Wang D, Liu M. Puerarin for ischaemic stroke. Cochrane Database Syst Rev. 2016 Feb 18;2:CD004955. doi: 10.1002/14651858.CD004955.pub3. Review. PubMed PMID: 26891451.

15: Guo HD, Zhang QF, Chen JG, Shangguang XC, Guo YX. Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 1;980:8-15. doi: 10.1016/j.jchromb.2014.12.014. PubMed PMID: 25553536.

16: Wang J, Zhang T, Ma C, Wang S. Puerarin attenuates airway inflammation by regulation of eotaxin-3. Immunol Lett. 2015 Feb;163(2):173-8. doi: 10.1016/j.imlet.2014.12.002. PubMed PMID: 25530546.

17: Ji Y, Jiang P, Yan X. Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives. Biomed Res Int. 2016;2016:9821767. PubMed PMID: 27807543; PubMed Central PMCID: PMC5078636.

18: Li W, Zhao W, Wu Q, Lu Y, Shi J, Chen X. Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. J Diabetes Res. 2016;2016:8541520. doi: 10.1155/2016/8541520. PubMed PMID: 26881260; PubMed Central PMCID: PMC4736809.

19: Ge B, Zhang Z, Lam TT, Zuo Z. Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. Biopharm Drug Dispos. 2017 Jan;38(1):33-49. doi: 10.1002/bdd.2054. PubMed PMID: 27925234.

20: Gray SL, Lackey BR, Boone WR. Impact of kudzu and puerarin on sperm function. Reprod Toxicol. 2015 Jun;53:54-62. doi: 10.1016/j.reprotox.2015.03.010. PubMed PMID: 25828059.