BAY-876
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530485

CAS#: 1799753-84-6

Description: BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in vitro and high oral bioavailability in vivo. GLUT1 overexpression has been reported in many types of human cancers, including those of brain,6 breast, colon, kidney, lung, ovary, and prostate, and is correlated with advanced cancer stages and poor clinical outcomes.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3250
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 4650
Size
Price

50mg
USD 450
500mg
USD 2150
5g
USD 7850

BAY-876, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530485
Name: BAY-876
CAS#: 1799753-84-6
Chemical Formula: C24H16F4N6O2
Exact Mass: 496.1271
Molecular Weight: 496.4256
Elemental Analysis: C, 58.07; H, 3.25; F, 15.31; N, 16.93; O, 6.45


Synonym: BAY-876; BAY 876; BAY876.

IUPAC/Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-Quinolinedicarboxamide

InChi Key: BKLJDIJJOOQUFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H16F4N6O2/c1-12-20(21(24(26,27)28)33-34(12)11-14-4-2-13(10-29)3-5-14)32-23(36)17-9-19(22(30)35)31-18-8-15(25)6-7-16(17)18/h2-9H,11H2,1H3,(H2,30,35)(H,32,36)

SMILES Code: O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C=C4)C#N)N=C3C(F)(F)F)=O)=C1)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Siebeneicher H, Cleve A, Rehwinkel H, Neuhaus R, Heisler I, Müller T, Bauser
M, Buchmann B. Identification and Optimization of the First Highly Selective
GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Oct 19;11(20):2261-2271. doi:
10.1002/cmdc.201600276. PubMed PMID: 27552707; PubMed Central PMCID: PMC5095872.