Tafetinib

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527406

CAS#: 1032265-57-8

Description: Tafetinib is a vascular endothelial growth factor receptor (VEGFR) inhibitor for the treatment of solid tumors. Tafeinib is also a multi-targeted receptor tyrosine kinase (RTK) inhibitor.


Price and Availability

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Tafetinib is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527406
Name: Tafetinib
CAS#: 1032265-57-8
Chemical Formula: C24H29FN4O2
Exact Mass: 424.2275
Molecular Weight: 424.5204
Elemental Analysis: C, 67.90; H, 6.89; F, 4.48; N, 13.20; O, 7.54


Synonym: Tafetinib, SIM-010603, SIM010603, SIM 010603

IUPAC/Chemical Name: (Z)-N-(2-(diethylamino)ethyl)-7-(5-fluoro-2-oxoindolin-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide

InChi Key: KGSRYTUWXUESJK-FXBPSFAMSA-N

InChi Code: InChI=1S/C24H29FN4O2/c1-4-29(5-2)12-11-26-23(30)20-14(3)27-22-16(20)7-6-8-17(22)21-18-13-15(25)9-10-19(18)28-24(21)31/h9-10,13,27H,4-8,11-12H2,1-3H3,(H,26,30)(H,28,31)/b21-17-

SMILES Code: CCN(CCNC(C1=C(NC2=C1CCC/C2=C3C(NC4=CC=C(C=C/34)F)=O)C)=O)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shao F, Zhu T, Tang F, Liu X. Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:50-5. doi: 10.1016/j.jpba.2013.02.041. PubMed PMID: 23624508.

2: Mao Y, Xia Z, Zhang X, Zong Y, Zhu L, Yuan B, Lu G. Evaluation of subchronic toxicity of SIM010603, a potent inhibitor of receptor tyrosine kinase, after 28-day repeated oral administration in SD rats and beagle dogs. Food Chem Toxicol. 2012 May;50(5):1256-70. doi: 10.1016/j.fct.2012.02.007. PubMed PMID: 22343322.

3: Wang D, Tang F, Wang S, Jiang Z, Zhang L. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor. Cancer Chemother Pharmacol. 2012 Jan;69(1):173-83. doi: 10.1007/s00280-011-1681-1. PubMed PMID: 21638122.