ZCZ011

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530477

CAS#: 1998197-39-9

Description: ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 potentiated binding of [(3)H]CP55,940 to the CB1 receptor as well as enhancing AEA-stimulated [(35)S]GTPγS binding in mouse brain membranes and β-arrestin recruitment and ERK phosphorylation in hCB1 cells. In the whole animal, ZCZ011 is brain penetrant, increased the potency of these orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, including antinociception, hypothermia, catalepsy, locomotor activity, and in the drug discrimination paradigm. ZCZ011 acts as a CB1 PAM and provide the first proof of principle that CB1 PAMs offer a promising strategy to treat neuropathic and inflammatory pain with minimal or no cannabimimetic side effects.


Price and Availability

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ZCZ011 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530477
Name: ZCZ011
CAS#: 1998197-39-9
Chemical Formula: C21H18N2O2S
Exact Mass: 362.1089
Molecular Weight: 362.447
Elemental Analysis: C, 69.59; H, 5.01; N, 7.73; O, 8.83; S, 8.85


Synonym: ZCZ011; ZCZ-011; ZCZ 011.

IUPAC/Chemical Name: 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole

InChi Key: RJSPNRDBWHHFMH-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3

SMILES Code: O=[N+](CC(C1=C(C2=CC=CC=C2)NC3=C1C=CC(C)=C3)C4=CC=CS4)[O-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA,
Damaj IM, Poklis J, Wiley JL, Zanda M, Zanato C, Greig IR, Lichtman AH, Ross RA.
A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain
in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015
Dec;40(13):2948-59. doi: 10.1038/npp.2015.148. PubMed PMID: 26052038; PubMed
Central PMCID: PMC4864630.