Guanoclor | CAS#5001-32-1 | antihypertensive

Guanoclor
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329525

CAS#: 5001-32-1

Description: Guanoclor is an antihypertensive drug.

Chemical Structure

Guanoclor

CAS# 5001-32-1

Instruction

Theoretical Analysis

MedKoo Cat#: 329525
Name: Guanoclor
CAS#: 5001-32-1
Chemical Formula: C9H12Cl2N4O
Exact Mass: 262.04
Molecular Weight: 263.122
Elemental Analysis: C, 41.08; H, 4.60; Cl, 26.95; N, 21.29; O, 6.08

Price and Availability

Size	Price	Availability	Quantity
1g	USD 1650
2g	USD 2950
5g	USD 4250
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Guanoclor; VATENSOL.

IUPAC/Chemical Name: 2-(2-(2,6-dichlorophenoxy)ethyl)hydrazine-1-carboximidamide

InChi Key: XIHXRRMCNSMUET-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H12Cl2N4O/c10-6-2-1-3-7(11)8(6)16-5-4-14-15-9(12)13/h1-3,14H,4-5H2,(H4,12,13,15)

SMILES Code: N=C(NNCCOC1=C(Cl)C=CC=C1Cl)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 263.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: SINNIAH R, GATENBY PB. CLINICOPHARMACOLOGICAL ASSESSMENT OF THE NEW ANTI-HYPERTENSIVE COMPOUND GUANOCLOR (VATENSOL). Ir J Med Sci. 1965 Mar;471:111-24. PubMed PMID: 14295356.

2: BENDER S. TO-DAY'S DRUGS. GUANOCLOR. Br Med J. 1964 Jul 25;2(5403):238-9. PubMed PMID: 14150915; PubMed Central PMCID: PMC1817852.

3: Mackinnon J, el-Baz LM. A comparison of guanoclor and methyldopa in the treatment of severe hypertension. Br J Clin Pract. 1971 Mar;25(3):135-7. PubMed PMID: 4929159.

4: Mehta AB, Biswas AK, Pinto IJ, Sheth UK. Clinical assessment of the new antihypertensive Compound--1029 (Vatensol)--Guanoclor. Indian Heart J. 1967 Oct;19(4):322-8. PubMed PMID: 4870898.

5: Lawrie TD. Current therapeutics CXXXV.--Guanoclor. Practitioner. 1967 Aug;199(190):239-43. PubMed PMID: 6058648.

6: Hodge JV. Guanoclor as an antihypertensive drug. Br Med J. 1966 Oct 22;2(5520):981-4. PubMed PMID: 5921741; PubMed Central PMCID: PMC1944426.

7: Wahbi AA, Bedair MM, Galal SM, Gazy AA. Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods. J Pharm Biomed Anal. 1993 Aug;11(8):639-45. PubMed PMID: 8257728.

8: Frelin C, Vigne P, Barbry P, Lazdunski M. Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. Eur J Biochem. 1986 Jan 15;154(2):241-5. PubMed PMID: 3002793.

9: Vigne P, Lazdunski M, Frelin C. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur J Pharmacol. 1989 Jan 31;160(2):295-8. PubMed PMID: 2527160.

10: LAWRIE TD, LORIMER AR, MCALPINE SG, REINERT H. CLINICAL TRIAL AND PHARMACOLOGICAL STUDY OF COMPOUND 1029. ("VATENSOL"). Br Med J. 1964 Feb 15;1(5380):402-6. PubMed PMID: 14085968; PubMed Central PMCID: PMC1813383.

11: Ham NS. Conformational populations for antihistamines and antihypertensives in solution. J Pharm Sci. 1976 Apr;65(4):612-4. PubMed PMID: 5591.

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