TB5
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MedKoo CAT#: 530369

CAS#: 948841-07-4

Description: TB5 is a MAO-B inhibitor. TB5 showed the inhibitory activity and selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01 μm and 13.18, respectively. TB5 was found to be nontoxic at 5 and 25 μm, with 95.75 and 84.59 % viability among cells, respectively.

Chemical Structure

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TB5
CAS# 948841-07-4
Instruction

Theoretical Analysis

MedKoo Cat#: 530369
Name: TB5
CAS#: 948841-07-4
Chemical Formula: C15H14BrNOS
Exact Mass: 335.00
Molecular Weight: 336.247
Elemental Analysis: C, 53.58; H, 4.20; Br, 23.76; N, 4.17; O, 4.76; S, 9.53

Price and Availability

Size Price Availability Quantity
100mg USD 550
200mg USD 950
500mg USD 1650
1g USD 2650
2g USD 3950
5g USD 5950
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Synonym: TB5, TB 5, TB-5

IUPAC/Chemical Name: (2E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one

InChi Key: PTLDLBSWTKNYCY-VMPITWQZSA-N

InChi Code: InChI=1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+

SMILES Code: O=C(C1=CC=C(Br)S1)/C=C/C2=CC=C(N(C)C)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 336.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mathew B, Haridas A, Uçar G, Baysal I, Joy M, Mathew GE, Lakshmanan B, Jayaprakash V. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71. doi: 10.1002/cmdc.201600122. PubMed PMID: 27159243.