Relacorilant

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329510

CAS#: 1496510-51-0

Description: Relacorilant is discontinued.

Chemical Structure

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Relacorilant
CAS# 1496510-51-0
Instruction

Theoretical Analysis

MedKoo Cat#: 329510
Name: Relacorilant
CAS#: 1496510-51-0
Chemical Formula: C27H22F4N6O3S
Exact Mass: 586.14
Molecular Weight: 586.566
Elemental Analysis: C, 55.29; H, 3.78; F, 12.96; N, 14.33; O, 8.18; S, 5.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Relacorilant, CORT125134; CORT-125134; CORT 125134.

IUPAC/Chemical Name: [(4aR)-1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazole-4-sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin- 2-yl]methanone

InChi Key: WANIDIGFXJFFEL-SANMLTNESA-N

InChi Code: InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1

SMILES Code: O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C1CCN(S(=O)(C5=CN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 586.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J,
Phillips T, Swift D, Eaton E. Identification of the Clinical Candidate
(R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexah
ydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methano
ne (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem.
2017 Apr 17. doi: 10.1021/acs.jmedchem.7b00162. [Epub ahead of print] PubMed
PMID: 28368581.


2: Bali U, Phillips T, Hunt H, Unitt J. FKBP5 mRNA Expression Is a Biomarker for
GR Antagonism. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. Epub 2016 Jul
26. PubMed PMID: 27459525.


3: Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF,
Conzen SD. Glucocorticoid receptor activation inhibits chemotherapy-induced cell
death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015
Sep;138(3):656-62. doi: 10.1016/j.ygyno.2015.06.033. Epub 2015 Jun 24. PubMed
PMID: 26115975; PubMed Central PMCID: PMC4556542.