Lanabecestat free base| AZD3293 | LY3314814 | CAS#1383982-64-6 | BACE1 inhibitor

Lanabecestat free base
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206783

CAS#: 1383982-64-6 (free base)

Description: Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ.

Chemical Structure

Lanabecestat free base

CAS# 1383982-64-6 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 206783
Name: Lanabecestat free base
CAS#: 1383982-64-6 (free base)
Chemical Formula: C26H28N4O
Exact Mass: 412.23
Molecular Weight: 412.537
Elemental Analysis: C, 75.70; H, 6.84; N, 13.58; O, 3.88

Price and Availability

Size	Price	Availability
5mg	USD 425	2 Weeks
10mg	USD 700	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1383986-31-9 (HCl) 1383982-64-6 (free base) 1628076-74-3 (deleted) 1522418-41-2 (camsylate)

Synonym: lanabecestat; AZD3293; AZD-3293; AZD 3293; LY3314814; LY-3314814; LY 3314814.

IUPAC/Chemical Name: (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

InChi Key: WKDNQONLGXOZRG-HDVKRFLQSA-N

InChi Code: InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26?

SMILES Code: NC(C(C)=N1)=NC21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@@]52CC[C@@H](OC)CC5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Eketjäll S, Janson J, Kaspersson K, Bogstedt A, Jeppsson F, Fälting J,
Haeberlein SB, Kugler AR, Alexander RC, Cebers G. AZD3293: A Novel, Orally Active
BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate
Kinetics. J Alzheimers Dis. 2016;50(4):1109-23. doi: 10.3233/JAD-150834. PubMed
PMID: 26890753; PubMed Central PMCID: PMC4927864.

2: Cebers G, Alexander RC, Haeberlein SB, Han D, Goldwater R, Ereshefsky L,
Olsson T, Ye N, Rosen L, Russell M, Maltby J, Eketjäll S, Kugler AR. AZD3293:
Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients
with Alzheimer's Disease. J Alzheimers Dis. 2017;55(3):1039-1053. PubMed PMID:
27767991.

3: Ghosh AK, Tang J. Prospects of β-Secretase Inhibitors for the Treatment of
Alzheimer's Disease. ChemMedChem. 2015 Sep;10(9):1463-6. doi:
10.1002/cmdc.201500216. PubMed PMID: 26140607.

Your view history

Lanabecestat free base featured