JK184
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406989

CAS#: 315703-52-7

Description: JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 can specially inhibit Gli in the Hedgehog (Hh) pathway, which showed great promise for cancer therapeutics.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3150
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 4650
Size
Price

50mg
USD 450
500mg
USD 1950
5g
Ask price

JK-184, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406989
Name: JK184
CAS#: 315703-52-7
Chemical Formula: C19H18N4OS
Exact Mass: 350.1201
Molecular Weight: 350.44
Elemental Analysis: C, 65.12; H, 5.18; N, 15.99; O, 4.57; S, 9.15


Synonym: JK-184; JK 184; JK184.

IUPAC/Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

InChi Key: ROYXIPOUVGDTAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)

SMILES Code: CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhang N, Liu S, Wang N, Deng S, Song L, Wu Q, Liu L, Su W, Wei Y, Xie Y, Gong
C. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth
through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb
14;7(6):2609-24. doi: 10.1039/c4nr06300g. PubMed PMID: 25581613.

2: Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK.
The imidazopyridine derivative JK184 reveals dual roles for microtubules in
Hedgehog signaling. Angew Chem Int Ed Engl. 2009;48(13):2321-4. doi:
10.1002/anie.200805666. PubMed PMID: 19222062.

3: Colavito SA, Zou MR, Yan Q, Nguyen DX, Stern DF. Significance of
glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast
cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of
activated B cells (NFκB) pathway. Breast Cancer Res. 2014 Sep 25;16(5):444. doi:
10.1186/s13058-014-0444-4. PubMed PMID: 25252859; PubMed Central PMCID:
PMC4303124.

4: Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S,
Cho CY, Schultz PG. A small-molecule antagonist of the hedgehog signaling
pathway. Chembiochem. 2007 Nov 5;8(16):1916-9. PubMed PMID: 17886323.