MDK71803

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 620112

CAS#: 137171-80-3

Description: MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol. MDK71803 has CAS#137171-80-3. We assigned a code name as MDK71803 (last 5 digital of its CAS# was used). Cefiderocol, also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa.


Chemical Structure

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MDK71803
CAS# 137171-80-3

Theoretical Analysis

MedKoo Cat#: 620112
Name: MDK71803
CAS#: 137171-80-3
Chemical Formula: C34H42ClN5O11S2
Exact Mass: 795.20
Molecular Weight: 796.304
Elemental Analysis: C, 51.28; H, 5.32; Cl, 4.45; N, 8.80; O, 22.10; S, 8.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MDK71803; MDK-71803; MDK 71803; Cefiderocol-intermediate, Cefiderocol-precursor.

IUPAC/Chemical Name: 4-methoxybenzyl (6R,7R)-7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

InChi Key:

InChi Code:

SMILES Code: O=C(N[C@@H]1C(N(C(C(OCC2=CC=C(OC)C=C2)=O)=C(CCl)C3)[C@]1([H])S3=O)=O)/C(C4=CSC(NC(OC(C)(C)C)=O)=N4)=N\OC(C)(C)C(OC(C)(C)C)=O

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 796.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Pharmaceutical preparation comprising cephalosporin having catechol groups with improved stability, and manufacture thereof. Kawasaki, Hidenori; Kojima, Natsuko; Fujihira, Atsushi; Takahashi, Kanako; Matsubara, Fumihiko; Matsuoka, Nao. PCT Int. Appl. (2016), WO 2016035846 A1 20160310. | Language: Japanese, Database: CAPLUS
2. Preparation of cephem compounds as antibacterial agents against β-lactamase-producing drug-resistant bacteria. Yamawaki, Kenji; Kusano, Hiroki. PCT Int. Appl. (2014), WO 2014104148 A1 20140703. | Language: Japanese, Database: CAPLUS
3. Preparation of cephem compounds having catechol group as antibacterial agents. Hisakawa, Shinya; Hasegawa, Yasushi; Aoki, Toshiaki; Kusano, Hiroki; Sano, Masayuki; Sato, Jun; Yamawaki, Kenji. PCT Int. Appl. (2011), WO 2011125967 A1 20111013. | Language: Japanese, Database: CAPLUS
4. Preparation of cephem compounds having pseudo-catechol group as antibacterial agents. Yamawaki, Kenji; Sugimoto, Hideki; Sano, Masayuki. PCT Int. Appl. (2011), WO 2011125966 A1 20111013. | Language: Japanese, Database: CAPLUS
5. Preparation of cephalosporins having catechol group as antibacterial agents
Quick View. Nishitani, Yasuhiro; Yamawaki, Kenji; Takeoka, Yusuke; Sugimoto, Hideki; Hisakawa, Shinya; Aoki, Toshiaki. PCT Int. Appl. (2010), WO 2010050468 A1 20100506. | Language: Japanese, Database: CAPLUS
6. Preparation of (piperaziniomethyl)cephalosporins. Onoue, Hiroshi; Konoike, Toshiro; Ishitobi, Hiroyuki. Eur. Pat. Appl. (1991), EP 416410 A1 19910313. | Language: English, Database: CAPLUS