Valtorcitabine dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530113

CAS#: 359689-54-6

Description: Valtorcitabine dihydrochloride is a DNA polymerase inhibitor potentially for the treatment of HBV infection.


Price and Availability

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Valtorcitabine dihydrochloride is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530113
Name: Valtorcitabine dihydrochloride
CAS#: 359689-54-6
Chemical Formula: C14H24Cl2N4O5
Exact Mass:
Molecular Weight: 399.27
Elemental Analysis: C, 42.12; H, 6.06; Cl, 17.76; N, 14.03; O, 20.04


Related CAS #: 359689-54-6(HCl)   380886-95-3 (free)  

Synonym: LDC-300; LDC300; LDC 300; NM-147; NM147; NM 147 monoVal-L-dC; L-dC; NV-02C; val-L-dC; LdC

IUPAC/Chemical Name: [(2S,3R,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] (2S)-2-amino-3-methylbutanoate;dihydrochloride

InChi Key: KDDUQKQRHQCADM-KRTNAVHJSA-N

InChi Code: InChI=1S/C14H22N4O5.2ClH/c1-7(2)12(16)13(20)23-8-5-11(22-9(8)6-19)18-4-3-10(15)17-14(18)21;;/h3-4,7-9,11-12,19H,5-6,16H2,1-2H3,(H2,15,17,21);2*1H/t8-,9+,11+,12+;;/m1../s1

SMILES Code: O=C1N=C(N)C=CN1[C@H]2C[C@@H]([C@@H](CO)O2)OC([C@@H](N)C(C)C)=O.[H]Cl.[H]Cl


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
380886-95-3(Valtorcitabine)
359689-54-6(Valtorcitabine dihydrochloride)


References

1: Keeffe EB, Marcellin P. New and emerging treatment of chronic hepatitis B. Clin Gastroenterol Hepatol. 2007 Mar;5(3):285-94. Review. PubMed PMID: 17218162.

2: Gish RG. Clinical trial results of new therapies for HBV: implications for treatment guidelines. Semin Liver Dis. 2005;25 Suppl 1:29-39. Review. PubMed PMID: 16103979.

3: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jan-Feb;27(1):49-77. PubMed PMID: 15834459.

4: Hodge RA. Telbivudine/Torcitabine Idenix/Novartis. Curr Opin Investig Drugs. 2004 Feb;5(2):232-41. Review. PubMed PMID: 15043399.