A-967079

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531374

CAS#: 1170613-55-4

Description: A-967079 is a selective TRPA1 channel blocker.


Price and Availability

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A-967079 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531374
Name: A-967079
CAS#: 1170613-55-4
Chemical Formula: C12H14FNO
Exact Mass: 207.1059
Molecular Weight: 207.2484
Elemental Analysis: C, 69.55; H, 6.81; F, 9.17; N, 6.76; O, 7.72


Synonym: A-967079

IUPAC/Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime

InChi Key: HKROEBDHHKMNBZ-CHBKHGQFSA-N

InChi Code: InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+

SMILES Code: CCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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2: Wang S, Zhai C, Zhang Y, Yu Y, Zhang Y, Ma L, Li S, Qiao Y. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21(9). pii: E1145. doi: 10.3390/molecules21091145. PubMed PMID: 27589700.

3: Chen Z, Du S, Kong C, Zhang Z, Mokhtar AD. Intrathecal administration of TRPA1 antagonists attenuate cyclophosphamide-induced cystitis in rats with hyper-reflexia micturition. BMC Urol. 2016 Jun 17;16(1):33. doi: 10.1186/s12894-016-0150-x. PubMed PMID: 27315798; PubMed Central PMCID: PMC4912737.

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5: Huang Q, Chen Y, Gong N, Wang YX. Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels. Metabolism. 2016 Apr;65(4):463-74. doi: 10.1016/j.metabol.2015.12.002. PubMed PMID: 26975538.

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7: Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015 Mar;16(3):167-78. doi: 10.1631/jzus.B1400189. PubMed PMID: 25743118; PubMed Central PMCID: PMC4357366.

8: Zhai C, Liu Q, Zhang Y, Wang S, Zhang Y, Li S, Qiao Y. Identification of natural compound carnosol as a novel TRPA1 receptor agonist. Molecules. 2014 Nov 14;19(11):18733-46. doi: 10.3390/molecules191118733. PubMed PMID: 25405290.

9: Banzawa N, Saito S, Imagawa T, Kashio M, Takahashi K, Tominaga M, Ohta T. Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist. J Biol Chem. 2014 Nov 14;289(46):31927-39. doi: 10.1074/jbc.M114.586891. PubMed PMID: 25271161; PubMed Central PMCID: PMC4231671.

10: Saarnilehto M, Chapman H, Savinko T, Lindstedt K, Lauerma AI, Koivisto A. Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. Allergy. 2014 Oct;69(10):1424-7. doi: 10.1111/all.12488. PubMed PMID: 25041656.

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12: Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A. TRPA1: a transducer and amplifier of pain and inflammation. Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):50-5. doi: 10.1111/bcpt.12138. Review. PubMed PMID: 24102997.

13: Wei H, Saarnilehto M, Falck L, Viisanen H, Lasierra M, Koivisto A, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A. J Physiol Pharmacol. 2013 Jun;64(3):331-40. PubMed PMID: 23959730.

14: Nakatsuka K, Gupta R, Saito S, Banzawa N, Takahashi K, Tominaga M, Ohta T. Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences. J Mol Neurosci. 2013 Nov;51(3):754-62. doi: 10.1007/s12031-013-0060-2. PubMed PMID: 23872983.

15: Schwartz ES, La JH, Scheff NN, Davis BM, Albers KM, Gebhart GF. TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci. 2013 Mar 27;33(13):5603-11. doi: 10.1523/JNEUROSCI.1806-12.2013. PubMed PMID: 23536075; PubMed Central PMCID: PMC3690366.

16: Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, Weigelt D, Dabrowski M. Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore. Biophys J. 2013 Feb 19;104(4):798-806. doi: 10.1016/j.bpj.2013.01.008. PubMed PMID: 23442958; PubMed Central PMCID: PMC3576529.

17: Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology. 2012 Jul;117(1):137-48. doi: 10.1097/ALN.0b013e31825adb0e. PubMed PMID: 22588108.

18: Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain. 2011 May;152(5):1165-72. doi: 10.1016/j.pain.2011.01.049. PubMed PMID: 21402443.

19: Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain. 2011 Mar;152(3):582-91. doi: 10.1016/j.pain.2010.11.031. PubMed PMID: 21211906.

20: McGaraughty S, Chu KL, Perner RJ, Didomenico S, Kort ME, Kym PR. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain. 2010 Mar 5;6:14. doi: 10.1186/1744-8069-6-14. PubMed PMID: 20205719; PubMed Central PMCID: PMC2841076.