A839977

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531368

CAS#: 870061-27-1

Description: A839977 is a P2X7R antagonist.


Price and Availability

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Price

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Price

A839977 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531368
Name: A839977
CAS#: 870061-27-1
Chemical Formula: C19H14Cl2N6O
Exact Mass: 412.0606
Molecular Weight: 413.262
Elemental Analysis: C, 55.22; H, 3.41; Cl, 17.16; N, 20.34; O, 3.87


Synonym: A839977

IUPAC/Chemical Name: 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine

InChi Key: GMVNBKZQJFRFAR-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14Cl2N6O/c20-14-7-5-8-15(18(14)21)27-19(24-25-26-27)23-12-13-6-1-2-9-16(13)28-17-10-3-4-11-22-17/h1-11H,12H2,(H,23,24,26)

SMILES Code: ClC1=C(Cl)C(N2N=NN=C2NCC3=CC=CC=C3OC4=NC=CC=C4)=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yang YL, Sun W, Peng C, Zhang XY, Yang XH. [Research progress of selective mGluR1 antagonists]. Yao Xue Xue Bao. 2011 Oct;46(10):1167-72. Review. Chinese. PubMed PMID: 22242445. 2: Zhu CZ, Baker S, EI-Kouhen O, Lehto SG, Hollingsworth PR, Gauvin DM, Hernandez G, Zheng G, Chang R, Moreland RB, Stewart AO, Brioni JD, Honore P. Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. Eur J Pharmacol. 2008 Feb 12;580(3):314-21. PubMed PMID: 18054908. 3: Zheng GZ, Bhatia P, Daanen J, Kolasa T, Patel M, Latshaw S, El Kouhen OF, Chang R, Uchic ME, Miller L, Nakane M, Lehto SG, Honore MP, Moreland RB, Brioni JD, Stewart AO. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. PubMed PMID: 16279797. 1: Falk S, Schwab SD, Frøsig-Jørgensen M, Clausen RP, Dickenson AH, Heegaard AM. P2X7 receptor-mediated analgesia in cancer-induced bone pain. Neuroscience. 2015 Apr 16;291:93-105. doi: 10.1016/j.neuroscience.2015.02.011. PubMed PMID: 25686524.