U-93631
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530441

CAS#: 152273-12-6

Description: U-93631 is a GABAA receptor antagonist. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.


Price and Availability

Size
Price

50mg
USD 250
500mg
USD 1650
5g
Ask price
Size
Price

100mg
USD 450
1g
USD 2950
Size
Price

200mg
USD 750
2g
USD 3950

U93631, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 530441
Name: U-93631
CAS#: 152273-12-6
Chemical Formula: C17H21N3O2
Exact Mass: 299.1634
Molecular Weight: 299.374
Elemental Analysis: C, 68.20; H, 7.07; N, 14.04; O, 10.69


Synonym: U93631, U-93631, U 93631

IUPAC/Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester

InChi Key: NXBSEJKZKXIYMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21N3O2/c1-16(2,3)22-15(21)13-14-17(4,5)19-11-8-6-7-9-12(11)20(14)10-18-13/h6-10,19H,1-5H3

SMILES Code: O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Dillon GH, Im HK, Hamilton BJ, Carter DB, Gammill RB, Judge TM, Im WB. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors. Mol Pharmacol. 1993 Oct;44(4):860-5. PubMed PMID: 8232235.

2: Bell-Horner CL, Dibas M, Huang RQ, Drewe JA, Dillon GH. Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):47-55. PubMed PMID: 10719214.

3: Das P, Bell-Horner CL, Machu TK, Dillon GH. The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacology. 2003 Mar;44(4):431-8. PubMed PMID: 12646280.

4: Dillon GH, Im WB, Pregenzer JF, Carter DB, Hamilton BJ. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J Pharmacol Exp Ther. 1995 Feb;272(2):597-603. PubMed PMID: 7531762.

5: Dillon GH, Im WB, Carter DB, McKinley DD. Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype. Br J Pharmacol. 1995 Jun;115(3):539-45. PubMed PMID: 7582470; PubMed Central PMCID: PMC1908408.