A61603

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531359

CAS#: 750531-54-5

Description: A61603 is an alpha-1A adrenergic receptor.


Price and Availability

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A61603 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531359
Name: A61603
CAS#: 750531-54-5
Chemical Formula: C14H19N3O3S
Exact Mass: 309.1147
Molecular Weight: 309.384
Elemental Analysis: C, 54.35; H, 6.19; N, 13.58; O, 15.51; S, 10.36


Related CAS #: 107756-30-9 (HBr)   750531-54-5 (free base)  

Synonym: A61603

IUPAC/Chemical Name: N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide

InChi Key: OQFCXJDXHCDLHX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)

SMILES Code: CS(=O)(NC1=C2CCCC(C3=NCCN3)C2=CC=C1O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Skelly MJ, Ariwodola OJ, Weiner JL. Fear conditioning selectively disrupts noradrenergic facilitation of GABAergic inhibition in the basolateral amygdala. Neuropharmacology. 2017 Feb;113(Pt A):231-240. doi: 10.1016/j.neuropharm.2016.10.003. PubMed PMID: 27720769; PubMed Central PMCID: PMC5148638.

2: Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016 Apr;1(3):155-167. PubMed PMID: 27453955; PubMed Central PMCID: PMC4955869.

3: Thomas RC Jr, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS One. 2016 Jun 3;11(6):e0155238. doi: 10.1371/journal.pone.0155238. PubMed PMID: 27258143; PubMed Central PMCID: PMC4892533.

4: Ge D, Yan X, Guo Y, Chen X, Guan R, Chen Y, Qiu D, Wang J. Activation of α1-adrenoceptors facilitates excitatory inputs to medullary airway vagal preganglionic neurons. J Appl Physiol (1985). 2015 Sep 15;119(6):686-95. doi: 10.1152/japplphysiol.00045.2015. PubMed PMID: 26205539.

5: Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H888-96. doi: 10.1152/ajpheart.00042.2015. PubMed PMID: 26116709; PubMed Central PMCID: PMC4591405.

6: Davis BJ, Wiener M, Chapple CR, Sellers DJ, Chess-Williams R. Functional and radioligand binding characterization of the α1L-adrenoceptor subtype of the human vas deferens. Auton Autacoid Pharmacol. 2015 Apr;34(3-4):41-9. doi: 10.1111/aap.12023. PubMed PMID: 25790239.

7: Ennis RC, Asico LD, Armando I, Yang J, Feranil JB, Jurgens JA, Escano CS Jr, Yu P, Wang X, Sibley DR, Jose PA, Villar VA. Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1238-48. doi: 10.1152/ajprenal.00119.2014. PubMed PMID: 25339698; PubMed Central PMCID: PMC4254972.

8: Yoshiki H, Uwada J, Umada H, Kobayashi T, Takahashi T, Yamakawa T, Yamaguchi A, Yokoyama O, Muramatsu I. Agonist pharmacology at recombinant α1A - and α1L -adrenoceptors and in lower urinary tract α1 -adrenoceptors. Br J Pharmacol. 2013 Nov;170(6):1242-52. doi: 10.1111/bph.12403. PubMed PMID: 24024968; PubMed Central PMCID: PMC3838699.

9: Amirak E, Fuller SJ, Sugden PH, Clerk A. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Biochem J. 2013 Mar 1;450(2):351-63. doi: 10.1042/BJ20121371. PubMed PMID: 23215897; PubMed Central PMCID: PMC3573779.

10: Moro C, Tajouri L, Chess-Williams R. Adrenoceptor function and expression in bladder urothelium and lamina propria. Urology. 2013 Jan;81(1):211.e1-7. doi: 10.1016/j.urology.2012.09.011. PubMed PMID: 23200975.

11: Martínez-Salas SG, Campos-Peralta JM, Pardo JP, Hernández-Muñoz R, Ibarra M, Tanoue A, Tsujimoto G, Villalobos-Molina R. α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice. Auton Autacoid Pharmacol. 2011 Jul-Oct;31(3-4):64-71. doi: 10.1111/j.1474-8673.2011.00468.x. PubMed PMID: 21951586.

12: Rank MM, Murray KC, Stephens MJ, D'Amico J, Gorassini MA, Bennett DJ. Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury. J Neurophysiol. 2011 Jan;105(1):410-22. doi: 10.1152/jn.00775.2010. PubMed PMID: 21047936; PubMed Central PMCID: PMC3023364.

13: Evans BA, Broxton N, Merlin J, Sato M, Hutchinson DS, Christopoulos A, Summers RJ. Quantification of functional selectivity at the human α(1A)-adrenoceptor. Mol Pharmacol. 2011 Feb;79(2):298-307. doi: 10.1124/mol.110.067454. Erratum in: Mol Pharmacol. 2011 Mar;79(3):627. PubMed PMID: 20978120.

14: Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME. Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Mol Pharmacol. 2009 Mar;75(3):713-28. doi: 10.1124/mol.108.050765. PubMed PMID: 19109357.

15: Mills K, Hausman N, Chess-Williams R. Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter. Br J Pharmacol. 2008 Sep;155(1):110-7. doi: 10.1038/bjp.2008.217. PubMed PMID: 18516067; PubMed Central PMCID: PMC2527848.

16: O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008 Jun 6;102(11):1378-88. doi: 10.1161/CIRCRESAHA.107.167734. PubMed PMID: 18467629.

17: Rojas Gomez DM, Schulte JS, Mohr FW, Dhein S. Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):77-85. doi: 10.1007/s00210-007-0244-9. PubMed PMID: 18193202.

18: Luo DL, Gao J, Fan LL, Tang Y, Zhang YY, Han QD. Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta Pharmacol Sin. 2007 Jul;28(7):968-74. PubMed PMID: 17588332.

19: Martínez-Salas SG, Campos-Peralta JM, Pares-Hipolito J, Gallardo-Ortíz IA, Ibarra M, Villalobos-Molina R. Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Auton Autacoid Pharmacol. 2007 Jul;27(3):137-42. PubMed PMID: 17584443.

20: Mehrotra S, Gupta S, Centurión D, Villalón CM, Saxena PR, VandenBrink AM. A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors. Basic Clin Pharmacol Toxicol. 2007 Apr;100(4):279-85. PubMed PMID: 17371533.