KCO-912

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530221

CAS#: 185695-83-4

Description: KCO-912 is an ATP-dependent K channel opener potentially for the treatment of asthma. It is a potent and selective opener of ATP-dependent potassium (K ATP) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects.


Price and Availability

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KCO-912 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530221
Name: KCO-912
CAS#: 185695-83-4
Chemical Formula: C22H26N2O5S
Exact Mass: 430.1562
Molecular Weight: 430.519
Elemental Analysis: C, 61.38; H, 6.09; N, 6.51; O, 18.58; S, 7.45


Synonym: KCO-912; KCO 912; KCO912

IUPAC/Chemical Name: (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-N-phenylchromane-6-sulfonamide

InChi Key: GPTKKIOZEZUGBH-RTWAWAEBSA-N

InChi Code: InChI=1S/C22H26N2O5S/c1-22(2)21(26)20(24-13-7-6-10-19(24)25)17-14-16(11-12-18(17)29-22)30(27,28)23-15-8-4-3-5-9-15/h3-5,8-9,11-12,14,20-21,23,26H,6-7,10,13H2,1-2H3/t20-,21+/m1/s1

SMILES Code: O=S(C1=CC=C2C([C@@H](N3C(CCCC3)=O)[C@H](O)C(C)(C)O2)=C1)(NC4=CC=CC=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: El-Hashim AZ, Buchheit KH, Fozard J, Page C. Effect of the K+(ATP) channel opener, KCO912, on baseline and allergen induced airway hyperresponsiveness in allergic rabbits. Eur J Pharmacol. 2004 Jan 26;484(2-3):351-6. PubMed PMID: 14744622.

2: Buchheit KH, Manley PW, Quast U, Russ U, Mazzoni L, Fozard JR. KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects. Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):220-30. PubMed PMID: 11882918.

3: Black KL, Yin D, Konda BM, Wang X, Hu J, Ko MK, Bayan JA, Sacapano MR, Espinoza AJ, Ong JM, Irvin D, Shu Y. Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. Brain Res. 2008 Aug 28;1227:198-206. doi: 10.1016/j.brainres.2008.06.046. PubMed PMID: 18602898; PubMed Central PMCID: PMC2605468.