N-5984

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530218

CAS#: 220475-76-3

Description: N-5984, also known as KRP-204, is A β3-adrenergic receptor agonist potentially for the treatment of obesity, overactive bladder and type 2 diabetes.


Price and Availability

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Price

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N-5984 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530218
Name: N-5984
CAS#: 220475-76-3
Chemical Formula: C20H22ClNO5
Exact Mass: 391.1187
Molecular Weight: 391.848
Elemental Analysis: C, 61.30; H, 5.66; Cl, 9.05; N, 3.57; O, 20.41


Synonym: KRP-204; N-5984; KRP204; N5984; KRP 204; N 5984

IUPAC/Chemical Name: (R)-6-((R)-2-(((R)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

SMILES Code: O=C([C@@H]1OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2OC1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yanagisawa T, Sato T, Yamada H, Sukegawa J, Nunoki K. Selectivity and potency of agonists for the three subtypes of cloned human beta-adrenoceptors expressed in Chinese hamster ovary cells. Tohoku J Exp Med. 2000 Nov;192(3):181-93. PubMed PMID: 11249148.

2: Kleiven AR, Fernandez-Chacon A, Nordahl JH, Moland E, Espeland SH, Knutsen H, Olsen EM. Harvest Pressure on Coastal Atlantic Cod (Gadus morhua) from Recreational Fishing Relative to Commercial Fishing Assessed from Tag-Recovery Data. PLoS One. 2016 Mar 9;11(3):e0149595. doi: 10.1371/journal.pone.0149595. Erratum in: PLoS One. 2016;11(7):e0159220. PubMed PMID: 26959371; PubMed Central PMCID: PMC4784990.

3: Hjørnevik LV, Frøyset AK, Grønset TA, Rungruangsak-Torrissen K, Fladmark KE. Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry. Mar Drugs. 2015 Dec 14;13(12):7390-402. doi: 10.3390/md13127072. PubMed PMID: 26694421; PubMed Central PMCID: PMC4699245.

4: Hevrøy EM, Tipsmark CK, Remø SC, Hansen T, Fukuda M, Torgersen T, Vikeså V, Olsvik PA, Waagbø R, Shimizu M. Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature. Comp Biochem Physiol A Mol Integr Physiol. 2015 Oct;188:127-38. doi: 10.1016/j.cbpa.2015.06.030. PubMed PMID: 26144599.

5: Unajak S, Meesawat P, Paemanee A, Areechon N, Engkagul A, Kovitvadhi U, Kovitvadhi S, Rungruangsak-Torrissen K, Choowongkomon K. Characterisation of thermostable trypsin and determination of trypsin isozymes from intestine of Nile tilapia (Oreochromis niloticus L.). Food Chem. 2012 Oct 1;134(3):1533-41. doi: 10.1016/j.foodchem.2012.03.074. PubMed PMID: 25005977.

6: Oxley A, Jolly C, Eide T, Jordal AE, Svardal A, Olsen RE. The combined impact of plant-derived dietary ingredients and acute stress on the intestinal arachidonic acid cascade in Atlantic salmon (Salmo salar). Br J Nutr. 2010 Mar;103(6):851-61. doi: 10.1017/S0007114509992467. PubMed PMID: 19943982.

7: Nordgarden U, Fjelldal PG, Hansen T, Björnsson BT, Wargelius A. Growth hormone and insulin-like growth factor-I act together and independently when regulating growth in vertebral and muscle tissue of atlantic salmon postsmolts. Gen Comp Endocrinol. 2006 Dec;149(3):253-60. PubMed PMID: 16890227.

8: Oxley A, Jutfelt F, Sundell K, Olsen RE. Sn-2-monoacylglycerol, not glycerol, is preferentially utilised for triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar L.) intestine. Comp Biochem Physiol B Biochem Mol Biol. 2007 Jan;146(1):115-23. PubMed PMID: 17126582.

9: Rungruangsak-Torrissen K, Moss R, Andresen LH, Berg A, Waagbø R. Different expressions of trypsin and chymotrypsin in relation to growth in Atlantic salmon (Salmo salar L.). Fish Physiol Biochem. 2006 Mar;32(1):7-23. doi: 10.1007/s10695-005-0630-5. PubMed PMID: 20035474; PubMed Central PMCID: PMC3233903.

10: Oxley A, Tocher DR, Torstensen BE, Olsen RE. Fatty acid utilisation and metabolism in caecal enterocytes of rainbow trout (Oncorhynchus mykiss) fed dietary fish or copepod oil. Biochim Biophys Acta. 2005 Dec 15;1737(2-3):119-29. PubMed PMID: 16257262.

11: Wargelius A, Fjelldal PG, Benedet S, Hansen T, Björnsson BT, Nordgarden U. A peak in gh-receptor expression is associated with growth activation in Atlantic salmon vertebrae, while upregulation of igf-I receptor expression is related to increased bone density. Gen Comp Endocrinol. 2005 May 15;142(1-2):163-8. PubMed PMID: 15862560.

12: Oxley A, Torstensen BE, Rustan AC, Olsen RE. Enzyme activities of intestinal triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar L.). Comp Biochem Physiol B Biochem Mol Biol. 2005 May;141(1):77-87. PubMed PMID: 15820137.