Manifaxine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530205

CAS#: 135306-39-7 (free base)

Description: Manifaxine is a norepinephrine-dopamine reuptake inhibitor potentially for the treatment of attention deficit.


Price and Availability

Size
Price

Size
Price

Size
Price

Manifaxine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 530205
Name: Manifaxine
CAS#: 135306-39-7 (free base)
Chemical Formula: C12H15F2NO2
Exact Mass: 243.1071
Molecular Weight: 243.2538
Elemental Analysis: C, 59.25; H, 6.22; F, 15.62; N, 5.76; O, 13.15


Synonym: BW-1555U-88; GW-320659; 1555U-88; BW1555U88; GW320659; 1555U88; BW 1555U 88; GW 320659; 1555U 88

IUPAC/Chemical Name: (2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5-dimethylmorpholin-2-ol

InChi Key: OZGPVYJHWWPEFT-RGNHYFCHSA-N

InChi Code: InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1

SMILES Code: O[C@]1(C2=CC(F)=CC(F)=C2)[C@H](C)N[C@H](C)CO1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS No.
135306-39-7 (Manifaxine)
135306-42-2 (Manifaxine hydrochloride)


References

1: Spraggs CF, Pillai SG, Dow D, Douglas C, McCarthy L, Manasco PK, Stubbins M, Roses AD. Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. PubMed PMID: 16272960.

2: DeVeaugh-Geiss J, Conners CK, Sarkis EH, Winner PK, Ginsberg LD, Hemphill JM, Laurenza A, Barrows CE, Webster CJ, Stotka CJ, Asgharnejad M. GW320659 for the treatment of attention-deficit/hyperactivity disorder in children. J Am Acad Child Adolesc Psychiatry. 2002 Aug;41(8):914-20. PubMed PMID: 12162627.