Fexarine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531135

CAS#: 574013-67-5

Description: Fexarine is a potent, selective farnesoid X receptor agonist.


Chemical Structure

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Fexarine
CAS# 574013-67-5

Theoretical Analysis

MedKoo Cat#: 531135
Name: Fexarine
CAS#: 574013-67-5
Chemical Formula: C31H31NO5
Exact Mass: 497.22
Molecular Weight: 497.591
Elemental Analysis: C, 74.83; H, 6.28; N, 2.81; O, 16.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Fexarine

IUPAC/Chemical Name: 3-{3-[(4-Benzo[1,3]dioxol-5-yl-benzyl)-cyclohexanecarbonyl-amino]-phenyl}-acrylic acid methyl ester

InChi Key: KHSMMANSTJCCLG-SFQUDFHCSA-N

InChi Code: InChI=1S/C31H31NO5/c1-35-30(33)17-12-22-6-5-9-27(18-22)32(31(34)25-7-3-2-4-8-25)20-23-10-13-24(14-11-23)26-15-16-28-29(19-26)37-21-36-28/h5-6,9-19,25H,2-4,7-8,20-21H2,1H3/b17-12+

SMILES Code: O=C(OC)/C=C/C1=CC=CC(N(CC2=CC=C(C3=CC=C(OCO4)C4=C3)C=C2)C(C5CCCCC5)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 497.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dental Space Maintainers for the Management of Premature Loss of Deciduous Molars: A Review of the Clinical Effectiveness, Cost-effectiveness and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Oct 20. Available from http://www.ncbi.nlm.nih.gov/books/NBK401552/ PubMed PMID: 27929629.

2: Fluoride Varnishes for Dental Health: A Review of the Clinical Effectiveness, Cost-effectiveness and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Oct 26. Available from http://www.ncbi.nlm.nih.gov/books/NBK401511/ PubMed PMID: 27929626.

3: Ziebland S, Powell J, Briggs P, Jenkinson C, Wyke S, Sillence E, Harris P, Perera R, Mazanderani F, Martin A, Locock L, Kelly L, Booth M, Gann B, Newhouse N, Farmer A. Examining the role of patients’ experiences as a resource for choice and decision-making in health care: a creative, interdisciplinary mixed-method study in digital health. Southampton (UK): NIHR Journals Library; 2016 Nov. PubMed PMID: 27929620.

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14: Ghashut RA, Blackwell S, Ryan S, Willox L, McMillan DC, Kinsella J, Talwar D. Assessment of Asymmetrical Dimethylarginine metabolism in Patients with Critical Illness. Eur J Clin Invest. 2016 Dec 8. doi: 10.1111/eci.12710. [Epub ahead of print] PubMed PMID: 27930821.

15: Karwi QG, Bornbaum J, Boengler K, Torregrossa R, Whiteman M, Wood ME, Schulz R, Baxter GF. Ap39, A Mitochondria-Targeting Hydrogen Sulfide (H(2) s) Donor, Protects Against Myocardial Reperfusion Injury Independently Of Salvage Kinase Signalling. Br J Pharmacol. 2016 Dec 8. doi: 10.1111/bph.13688. [Epub ahead of print] PubMed PMID: 27930802.

16: Acton JH, Molik B, Court H, Margrain TH. Effect of a Home Visit-Based Low Vision Rehabilitation Intervention on Visual Function Outcomes: An Exploratory Randomized Controlled Trial. Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6662-6667. doi: 10.1167/iovs.16-19901. PubMed PMID: 27930779.

17: Khan KS, Gugiu MR, Justice LM, Bowles RP, Skibbe LE, Piasta SB. Age-Related Progressions in Story Structure in Young Children's Narratives. J Speech Lang Hear Res. 2016 Dec 8:1-14. doi: 10.1044/2016_JSLHR-L-15-0275. [Epub ahead of print] PubMed PMID: 27930767.

18: Sardarinia M, Akbarpour S, Lotfaliany M, Bagherzadeh-Khiabani F, Bozorgmanesh M, Sheikholeslami F, Azizi F, Hadaegh F. Risk Factors for Incidence of Cardiovascular Diseases and All-Cause Mortality in a Middle Eastern Population over a Decade Follow-up: Tehran Lipid and Glucose Study. PLoS One. 2016 Dec 8;11(12):e0167623. doi: 10.1371/journal.pone.0167623. PubMed PMID: 27930696.

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