Cambendazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329465

CAS#: 26097-80-3

Description: Cambendazole is one of the most effective agents for the therapy of human strongyloidiasis.


Price and Availability

Size
Price

10mg
USD 550
Size
Price

Size
Price

Cambendazole purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329465
Name: Cambendazole
CAS#: 26097-80-3
Chemical Formula: C14H14N4O2S
Exact Mass: 302.0837
Molecular Weight: 302.352
Elemental Analysis: C, 55.62; H, 4.67; N, 18.53; O, 10.58; S, 10.60


Synonym: Cambendazole; Novazole; Noviben; Equiben.

IUPAC/Chemical Name: isopropyl (2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)carbamate

InChi Key: QZWHWHNCPFEXLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)

SMILES Code: O=C(OC(C)C)NC1=CC=C2C(N=C(C3=CSC=N3)N2)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Andrade SR, Scarminio IS, Nery MM, de Oliveira AC. Comparison of multivariate calibration methods to determine simultaneously mebendazole-cambendazole and mebendazole-thiabendazole in pharmaceutical preparations by UV-visible spectrophotometry. J Pharm Biomed Anal. 2003 Nov 24;33(4):655-65. PubMed PMID: 14623591.

2: Lyons ET, Drudge JH, Tolliver SC, Swerczek TW, Stamper S, Granstrom DE. Control of cambendazole-resistant small strongyles (Population S) with oxibendazole in a pony band: an 8 year field test (1984-1992). Vet Parasitol. 1994 Apr;52(3-4):271-7. PubMed PMID: 8073610.

3: Sharma RK, Singh K, Saxena KK. Effect of cambendazole and haloxon on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae (Nematoda). Angew Parasitol. 1990 May;31(2):101-5. PubMed PMID: 2389827.

4: Grove DI, Northern C. The effects of thiabendazole, mebendazole and cambendazole in normal and immunosuppressed dogs infected with a human strain of Strongyloides stercoralis. Trans R Soc Trop Med Hyg. 1988;82(1):146-9. PubMed PMID: 3176142.

5: Karmańska K, Michalska Z, Slaska B, Mielczarek J. [Trial of the modification of immunopathological changes in the muscular phase of trichinosis I. The effect of cambendazole]. Wiad Parazytol. 1987;33(4-5):517-24. Polish. PubMed PMID: 3452944.

6: Dorny P, Berghen P, Vercruysse J. Morphological changes in Capillaria obsignata (Nematoda: Trichuridae) eggs after treatment with cambendazole. Parasitol Res. 1987;74(2):196-7. PubMed PMID: 3438301.

7: Grove DI, Northern C. Strongyloides ratti and S. stercoralis: effects of cambendazole, thiabendazole and mebendazole in vitro. Rev Inst Med Trop Sao Paulo. 1986 Mar-Apr;28(2):97-103. PubMed PMID: 3797953.

8: Drudge JH, Lyons ET, Tolliver SC, Swerczek TW. Use of oxibendazole for control of cambendazole-resistant small strongyles in a band of ponies: a six-year study. Am J Vet Res. 1985 Dec;46(12):2507-11. PubMed PMID: 4083584.

9: Bliss EL, Greiner EC. Efficacy of fenbendazole and cambendazole against Muellerius capillaris in dairy goats. Am J Vet Res. 1985 Sep;46(9):1923-5. PubMed PMID: 4051297.

10: McCracken RO, Garcia A, Nierste DM, Dock D. The effect of dosage regimen on the efficacy of cambendazole against Trichinella spiralis. Int J Parasitol. 1985 Jun;15(3):309-12. PubMed PMID: 4030205.

11: Kawalek JC, Rew RS, Heavner J. Glutathione-S-transferase, a possible drug-metabolizing enzyme, in Haemonchus contortus: comparative activity of a cambendazole-resistant and a susceptible strain. Int J Parasitol. 1984 Apr;14(2):173-5. PubMed PMID: 6735580.

12: Bicalho SA, Leão OJ, Pena Q Jr. Cambendazole in the treatment of human strongyloidiasis. Am J Trop Med Hyg. 1983 Sep;32(5):1181-3. PubMed PMID: 6625071.

13: McCracken RO, Taylor DD. Biochemical effects of thiabendazole and cambendazole on Hymenolepis diminuta (Cestoda) in vivo. J Parasitol. 1983 Apr;69(2):295-301. PubMed PMID: 6854471.

14: Drudge JH, Lyons ET, Swerczek TW, Tolliver SC. Cambendazole for strongyle control in a pony band: selection of a drug-resistant population of small strongyles and teratologic implications. Am J Vet Res. 1983 Jan;44(1):110-4. PubMed PMID: 6824213.

15: Barański MC, da Silva AF, Kotaka PI, Gomes NR, Giovannoni M, Telles JE. Treatment of human strongyloidiasis with cambendazole, a new anthelminthic. Double-blind study. Mater Med Pol. 1983 Jan-Jun;15(1-2):36-8. PubMed PMID: 6400164.

16: Mirck MH, van Meurs GK. [Effect of albendazole and cambendazole on the egg output of Strongylidae in horses]. Tijdschr Diergeneeskd. 1982 Oct 1;107(19):731-6. Dutch. PubMed PMID: 7147218.

17: Grove DI. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice. Am J Trop Med Hyg. 1982 May;31(3 Pt 1):469-76. PubMed PMID: 7081540.

18: Herlich H, Rew RS, Colglazier ML. Inheritance of cambendazole resistance in Haemonchus contortus. Am J Vet Res. 1981 Aug;42(8):1342-4. PubMed PMID: 7294466.

19: Supperer R, Kutzer E. [Tolerance of mebendazole, fenbendazole, thiabendazole, cambendazole and febantel in relation to egg-laying capacity, egg quality, fertility and hatch rate of quail (Coturnix coturnix japonica)]. Berl Munch Tierarztl Wochenschr. 1981 Jun 1;94(11-12):211-5. German. PubMed PMID: 6895027.

20: Evans WS, Hardy M, Novak M. A comparison of the effect of albendazole, cambendazole, and thiabendazole on the larval development of three hymenolepidid cestodes. J Parasitol. 1980 Dec;66(6):935-40. PubMed PMID: 7218116.