A-804598
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530351

CAS#: 1125758-85-1

Description: A-804598 is a P2X7 selective, competitive antagonist.


Price and Availability

Size
Price

5mg
USD 225
Size
Price

10mg
USD 390
Size
Price

25mg
USD 785

A-804598 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530351
Name: A-804598
CAS#: 1125758-85-1
Chemical Formula: C19H17N5
Exact Mass: 315.1484
Molecular Weight: 315.38
Elemental Analysis: C, 72.36; H, 5.43; N, 22.21


Synonym: A-804598; A 804598; A804598.

IUPAC/Chemical Name: N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine

InChi Key: PQYCRDPLPKGSME-AWEZNQCLSA-N

InChi Code: InChI=1S/C19H17N5/c1-14(15-7-3-2-4-8-15)23-19(22-13-20)24-18-11-5-10-17-16(18)9-6-12-21-17/h2-12,14H,1H3,(H2,22,23,24)/t14-/m0/s1

SMILES Code: C[C@H](/N=C(NC1=C2C=CC=NC2=CC=C1)/NC#N)C3=CC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lord B, Ameriks MK, Wang Q, Fourgeaud L, Vliegen M, Verluyten W, Haspeslagh P,
Carruthers NI, Lovenberg TW, Bonaventure P, Letavic MA, Bhattacharya A. A novel
radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334. Eur J
Pharmacol. 2015 Oct 15;765:551-9. doi: 10.1016/j.ejphar.2015.09.026. PubMed PMID:
26386289.

2: Antonioli L, Giron MC, Colucci R, Pellegrini C, Sacco D, Caputi V, Orso G,
Tuccori M, Scarpignato C, Blandizzi C, Fornai M. Involvement of the P2X7
purinergic receptor in colonic motor dysfunction associated with bowel
inflammation in rats. PLoS One. 2014 Dec 30;9(12):e116253. doi:
10.1371/journal.pone.0116253. PubMed PMID: 25549098; PubMed Central PMCID:
PMC4280204.

3: Catanzaro JM, Hueston CM, Deak MM, Deak T. The impact of the P2X7 receptor
antagonist A-804598 on neuroimmune and behavioral consequences of stress. Behav
Pharmacol. 2014 Sep;25(5-6):582-98. doi: 10.1097/FBP.0000000000000072. PubMed
PMID: 25083574.

4: Able SL, Fish RL, Bye H, Booth L, Logan YR, Nathaniel C, Hayter P, Katugampola
SD. Receptor localization, native tissue binding and ex vivo occupancy for
centrally penetrant P2X7 antagonists in the rat. Br J Pharmacol. 2011
Jan;162(2):405-14. doi: 10.1111/j.1476-5381.2010.01025.x. PubMed PMID: 20840537;
PubMed Central PMCID: PMC3031061.

5: Donnelly-Roberts DL, Namovic MT, Surber B, Vaidyanathan SX, Perez-Medrano A,
Wang Y, Carroll WA, Jarvis MF. [3H]A-804598
([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent,
and selective antagonist radioligand for P2X7 receptors. Neuropharmacology. 2009
Jan;56(1):223-9. doi: 10.1016/j.neuropharm.2008.06.012. PubMed PMID: 18602931.