C16 (PKR Inhibitor)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530346

CAS#: 608512-97-6

Description: C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4.


Price and Availability

Size
Price

5mg
USD 150
Size
Price

10mg
USD 250
Size
Price

25mg
USD 450

C16 (PKR Inhibitor), purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530346
Name: C16 (PKR Inhibitor)
CAS#: 608512-97-6
Chemical Formula: C13H8N4OS
Exact Mass: 268.0419
Molecular Weight: 268.294
Elemental Analysis: C, 58.20; H, 3.01; N, 20.88; O, 5.96; S, 11.95


Synonym: GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor.

IUPAC/Chemical Name: 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

InChi Key: VFBGXTUGODTSPK-BAQGIRSFSA-N

InChi Code: InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

SMILES Code: O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4


Technical Data

Appearance:
Solid powder

Purity:
>95% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Naz F, Shahbaaz M, Khan S, Bisetty K, Islam A, Ahmad F, Hassan MI. PKR-inhibitor binds efficiently with human microtubule affinity-regulating kinase 4. J Mol Graph Model. 2015 Nov;62:245-52. doi: 10.1016/j.jmgm.2015.10.009. PubMed PMID: 26519933.

2: Tronel C, Page G, Bodard S, Chalon S, Antier D. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83. doi: 10.1016/j.neuint.2013.10.012. PubMed PMID: 24211709.

3: Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication. Retrovirology. 2013 Sep 11;10:96. doi: 10.1186/1742-4690-10-96. PubMed PMID: 24020926; PubMed Central PMCID: PMC3848765.

4: Bilgin DD, Liu Y, Schiff M, Dinesh-Kumar SP. P58(IPK), a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Dev Cell. 2003 May;4(5):651-61. PubMed PMID: 12737801.

5: Gerotto M, Dal Pero F, Pontisso P, Noventa F, Gatta A, Alberti A. Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon. Gastroenterology. 2000 Dec;119(6):1649-55. PubMed PMID: 11113086.