AC-55541
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530338

CAS#: 916170-19-9

Description: AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 2450
Size
Price

25mg
USD 150
200mg
USD 650
2g
USD 3850
Size
Price

50mg
USD 250
500mg
USD 1350
5g
USD 4750

AC-55541, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530338
Name: AC-55541
CAS#: 916170-19-9
Chemical Formula: C25H20BrN5O3
Exact Mass: 517.075
Molecular Weight: 518.371
Elemental Analysis: C, 57.93; H, 3.89; Br, 15.41; N, 13.51; O, 9.26


Synonym: AC-55541; AC 55541; AC55541.

IUPAC/Chemical Name: (E)-N-(2-(2-(1-(3-bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

InChi Key: UCUHFWIFSHROPY-RWPZCVJISA-N

InChi Code: InChI=1S/C25H20BrN5O3/c1-15(17-10-7-11-18(26)14-17)28-31-25(34)22(27-23(32)16-8-3-2-4-9-16)21-19-12-5-6-13-20(19)24(33)30-29-21/h2-14,22H,1H3,(H,27,32)(H,30,33)(H,31,34)/b28-15+

SMILES Code: O=C1C2=CC=CC=C2C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Homma T, Kato A, Bhushan B, Norton JE, Suh LA, Carter RG, Gupta DS, Schleimer
RP. Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in
Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias. Am J
Respir Cell Mol Biol. 2016 Jan;54(1):60-70. doi: 10.1165/rcmb.2015-0062OC. PubMed
PMID: 26072921; PubMed Central PMCID: PMC4742929.

2: Ma JN, Burstein ES. The protease activated receptor 2 (PAR2) polymorphic
variant F240S constitutively activates PAR2 receptors and potentiates responses
to small-molecule PAR2 agonists. J Pharmacol Exp Ther. 2013 Dec;347(3):697-704.
doi: 10.1124/jpet.113.208744. PubMed PMID: 24078870.

3: Gardell LR, Ma JN, Seitzberg JG, Knapp AE, Schiffer HH, Tabatabaei A, Davis
CN, Owens M, Clemons B, Wong KK, Lund B, Nash NR, Gao Y, Lameh J, Schmelzer K,
Olsson R, Burstein ES. Identification and characterization of novel
small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008
Dec;327(3):799-808. doi: 10.1124/jpet.108.142570. PubMed PMID: 18768780.