M2I-1
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MedKoo CAT#: 406954

CAS#: 312271-03-7

Description: M2I-1, also known as Mad2 Inhibitor-1, is Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells.


Price and Availability

Size
Price

100mg
USD 650
1g
USD 2250
Size
Price

200mg
USD 950
2g
USD 3850
Size
Price

500mg
USD 1450
5g
Ask price

M2I-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406954
Name: M2I-1
CAS#: 312271-03-7
Chemical Formula: C19H24N4O4S
Exact Mass: 404.1518
Molecular Weight: 404.485
Elemental Analysis: C, 56.42; H, 5.98; N, 13.85; O, 15.82; S, 7.93


Synonym: M2I-1; M2I1; M2I 1. Mad2 Inhibitor-1.

IUPAC/Chemical Name: 5-(4-(Diisobutylamino)-3-nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

InChi Key: BWEKPQUKWLNUKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H24N4O4S/c1-11(2)9-22(10-12(3)4)15-6-5-13(8-16(15)23(26)27)7-14-17(24)20-19(28)21-18(14)25/h5-8,11-12H,9-10H2,1-4H3,(H2,20,21,24,25,28)

SMILES Code: O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kastl J, Braun J, Prestel A, Möller HM, Huhn T, Mayer TU. Mad2 Inhibitor-1
(M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the
Mitotic Spindle Assembly Checkpoint. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.
doi: 10.1021/acschembio.5b00121. PubMed PMID: 25978000.