Belaperidone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329443

CAS#: 208661-17-0

Description: Belaperidone, also known as LU-111995, is a novel antipsychotic drug in clinical development. It has a clozapine-like receptor profile and affinities for dopamine D(4) and 5-hydroxytryptamine(2A) receptors. LU111995 prolongs the Q-T interval to a limited degree and is not arrhythmogenic over the physiological range of CLs. LU-111995 exhibits potential antipsychotic-like activity in two models of disrupted PPI.


Price and Availability

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Belaperidone is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329443
Name: Belaperidone
CAS#: 208661-17-0
Chemical Formula: C22H22FN3O2
Exact Mass: 379.1696
Molecular Weight: 379.435
Elemental Analysis: C, 69.64; H, 5.84; F, 5.01; N, 11.07; O, 8.43


Synonym: LU-111995; LU 111995; LU111995; Belaperidone

IUPAC/Chemical Name: 3-(2-((1S,5R,6S)-6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)ethyl)quinazoline-2,4(1H,3H)-dione

InChi Key: XLJWJFKYRFPJSD-LZQZEXGQSA-N

InChi Code: InChI=1S/C22H22FN3O2/c23-16-7-5-14(6-8-16)18-11-15-12-25(13-19(15)18)9-10-26-21(27)17-3-1-2-4-20(17)24-22(26)28/h1-8,15,18-19H,9-13H2,(H,24,28)/t15-,18-,19+/m1/s1

SMILES Code: O=C(N1CCN2C[C@@]3([H])C[C@H](C4=CC=C(F)C=C4)[C@@]3([H])C2)NC5=C(C=CC=C5)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Geyer MA, Swerdlow NR, Lehmann-Masten V, Teschendorf HJ, Traut M, Gross G.
Effects of LU-111995 in three models of disrupted prepulse inhibition in rats. J
Pharmacol Exp Ther. 1999 Aug;290(2):716-24. PubMed PMID: 10411583.

2: Sosunov EA, Gainullin RZ, Danilo P Jr, Anyukhovsky EP, Kirchengast M, Rosen
MR. Electrophysiological effects of LU111995 on canine hearts: in vivo and in
vitro studies. J Pharmacol Exp Ther. 1999 Jul;290(1):146-52. PubMed PMID:
10381770.