Belaperidone

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MedKoo CAT#: 329443

CAS#: 208661-17-0

Description: Belaperidone, also known as LU-111995, is a novel antipsychotic drug in clinical development. It has a clozapine-like receptor profile and affinities for dopamine D(4) and 5-hydroxytryptamine(2A) receptors. LU111995 prolongs the Q-T interval to a limited degree and is not arrhythmogenic over the physiological range of CLs. LU-111995 exhibits potential antipsychotic-like activity in two models of disrupted PPI.

Chemical Structure

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Belaperidone
CAS# 208661-17-0
Instruction

Theoretical Analysis

MedKoo Cat#: 329443
Name: Belaperidone
CAS#: 208661-17-0
Chemical Formula: C22H22FN3O2
Exact Mass: 379.17
Molecular Weight: 379.435
Elemental Analysis: C, 69.64; H, 5.84; F, 5.01; N, 11.07; O, 8.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: LU-111995; LU 111995; LU111995; Belaperidone

IUPAC/Chemical Name: 3-(2-((1S,5R,6S)-6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)ethyl)quinazoline-2,4(1H,3H)-dione

InChi Key: XLJWJFKYRFPJSD-LZQZEXGQSA-N

InChi Code: InChI=1S/C22H22FN3O2/c23-16-7-5-14(6-8-16)18-11-15-12-25(13-19(15)18)9-10-26-21(27)17-3-1-2-4-20(17)24-22(26)28/h1-8,15,18-19H,9-13H2,(H,24,28)/t15-,18-,19+/m1/s1

SMILES Code: O=C(N1CCN2C[C@@]3([H])C[C@H](C4=CC=C(F)C=C4)[C@@]3([H])C2)NC5=C(C=CC=C5)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 379.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Geyer MA, Swerdlow NR, Lehmann-Masten V, Teschendorf HJ, Traut M, Gross G.
Effects of LU-111995 in three models of disrupted prepulse inhibition in rats. J
Pharmacol Exp Ther. 1999 Aug;290(2):716-24. PubMed PMID: 10411583.


2: Sosunov EA, Gainullin RZ, Danilo P Jr, Anyukhovsky EP, Kirchengast M, Rosen
MR. Electrophysiological effects of LU111995 on canine hearts: in vivo and in
vitro studies. J Pharmacol Exp Ther. 1999 Jul;290(1):146-52. PubMed PMID:
10381770.