ABP-700 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527103

CAS#: ABP-700 HCl

Description: ABP-700 is a novel, positive allosteric modulator of the GABAA receptor currently being developed for the induction of general anesthesia and procedural sedation. ABP-700 shows the expected suppressive effects for BIS and MOAA/S. .


Chemical Structure

img
ABP-700 HCl
CAS# ABP-700 HCl

Theoretical Analysis

MedKoo Cat#: 527103
Name: ABP-700 HCl
CAS#: ABP-700 HCl
Chemical Formula: C17H19ClN2O4
Exact Mass: 314.13
Molecular Weight: 350.800
Elemental Analysis: C, 58.21; H, 5.46; Cl, 10.11; N, 7.99; O, 18.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1446482-29-6 (free base)   ABP-700 HCl    

Synonym: ABP-700 HCl; ABP-700 hydrochloride; ABP-700; ABP-700; ABP-700; CPMM;

IUPAC/Chemical Name: 1-(methoxycarbonyl)cyclopropyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride

InChi Key: JUXJYXKBJBBWBK-UTONKHPSSA-N

InChi Code: InChI=1S/C17H18N2O4.ClH/c1-12(13-6-4-3-5-7-13)19-11-18-10-14(19)15(20)23-17(8-9-17)16(21)22-2;/h3-7,10-12H,8-9H2,1-2H3;1H/t12-;/m1./s1

SMILES Code: O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OC3(C(OC)=O)CC3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 350.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE. Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 Aug;131(2):287-304. doi: 10.1097/ALN.0000000000002758. PMID: 31166238.


2: Valk BI, Absalom AR, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Struys MMRF. Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects. Br J Anaesth. 2018 Jun;120(6):1401-1411. doi: 10.1016/j.bja.2018.01.038. Epub 2018 Mar 28. PMID: 29793605.


3: Struys MMRF, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, den Daas I, Chou T, van Amsterdam K, Campagna JA, Sweeney SP. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose. Anesthesiology. 2017 Jul;127(1):20-35. doi: 10.1097/ALN.0000000000001662. PMID: 28459733.


4: Valk BI, Eleveld DJ, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Absalom AR, Struys MMRF. Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700. Anesthesiology. 2021 Jan 1;134(1):35-51. doi: 10.1097/ALN.0000000000003590. Erratum in: Anesthesiology. 2021 Jan 1;134(1):138. PMID: 33064833.


5: Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700: Erratum. Anesthesiology. 2021 Jan 1;134(1):138. doi: 10.1097/ALN.0000000000003618. Erratum for: Anesthesiology. 2021 Jan 1;134(1):35-51. PMID: 33137179.


6: Valk BI, Struys MMRF. Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2021 Jun 1. doi: 10.1007/s40262-021-01038-6. Epub ahead of print. PMID: 34060021.


7: Tejera E, Munteanu CR, López-Cortés A, Cabrera-Andrade A, Pérez-Castillo Y. Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease. Molecules. 2020 Nov 6;25(21):5172. doi: 10.3390/molecules25215172. PMID: 33172092; PMCID: PMC7664330.


8: Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl- methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec;121(6):1203-16. doi: 10.1097/ALN.0000000000000416. PMID: 25170571; PMCID: PMC4237671.