Farampator
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328099

CAS#: 211735-76-1

Description: Farampator, also known as Org-24448; CX-691, is an AMPA receptor positive allosteric modulator potentially for the treatment of schizophrenia.


Price and Availability

Size
Price

100mg
USD 850
1g
USD 2950
Size
Price

200mg
USD 1450
2g
USD 3850
Size
Price

500mg
USD 2150
5g
USD 5450

Farampator, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328099
Name: Farampator
CAS#: 211735-76-1
Chemical Formula: C12H13N3O2
Exact Mass: 231.1008
Molecular Weight: 231.255
Elemental Analysis: C, 62.33; H, 5.67; N, 18.17; O, 13.84


Synonym: Farampator; Org-24448; CX-691; Org24448; CX691.

IUPAC/Chemical Name: 1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine

InChi Key: XFVRBYKKGGDPAJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2

SMILES Code: O=C(N1CCCCC1)C2=CC3=NON=C3C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH. Differential
effects of AMPA receptor potentiators and glycine reuptake inhibitors on
antipsychotic efficacy and prefrontal glutamatergic transmission.
Psychopharmacology (Berl). 2012 May;221(1):115-31. doi:
10.1007/s00213-011-2554-3. PubMed PMID: 22068461.

2: Woolley ML, Waters KA, Gartlon JE, Lacroix LP, Jennings C, Shaughnessy F, Ong
A, Pemberton DJ, Harries MH, Southam E, Jones DN, Dawson LA. Evaluation of the
pro-cognitive effects of the AMPA receptor positive modulator,
5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.
Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. doi:
10.1007/s00213-008-1325-2. PubMed PMID: 18795266.

3: Dawson N, Ferrington L, Olverman HJ, Kelly PA. Novel analysis for improved
validity in semi-quantitative 2-deoxyglucose autoradiographic imaging. J Neurosci
Methods. 2008 Oct 30;175(1):25-35. doi: 10.1016/j.jneumeth.2008.07.020. PubMed
PMID: 18762213.

4: Wezenberg E, Verkes RJ, Ruigt GS, Hulstijn W, Sabbe BG. Acute effects of the
ampakine farampator on memory and information processing in healthy elderly
volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83. PubMed PMID:
17119538.

5: Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K. Regionally
selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on
local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose
autoradiography. Neuropharmacology. 2005 Aug;49(2):254-64. PubMed PMID: 15993447.