Sch 39304

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526311

CAS#: 120924-80-3

Description: Sch 39304 is a new oral triazole antifungal. Sch 39304 is a primary treatment of acute cryptococcal meningitis in HIV-infected patients.


Chemical Structure

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Sch 39304
CAS# 120924-80-3

Theoretical Analysis

MedKoo Cat#: 526311
Name: Sch 39304
CAS#: 120924-80-3
Chemical Formula: C13H15F2N3O3S
Exact Mass: 331.08
Molecular Weight: 331.340
Elemental Analysis: C, 47.13; H, 4.56; F, 11.47; N, 12.68; O, 14.49; S, 9.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Sch 39304; Sch39304; Sch-39304.

IUPAC/Chemical Name: 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-((1R)-1- (methylsulfonyl)ethyl)-, (alphaR)-rel-

InChi Key:

InChi Code:

SMILES Code: O[C@]([C@H](S(=O)(C)=O)C)(C1=CC=C(F)C=C1F)CN2N=CN=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Venkateswarlu K, Kelly SL. Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus. J Antimicrob Chemother. 1997 May;39(5):597-601. PubMed PMID: 9184358.

2: Kim H, Lin CC. A chiral liquid chromatographic method for the determination of the enantiomers of the racemic triazole antifungal drug (SCH 39304) in human plasma. J Pharm Biomed Anal. 1995 Oct;13(11):1415-9. PubMed PMID: 8634360.

3: Wallace JE, Mojaverian P, Lin CC, Kim HK, Harris SC, Chen TJ, Rinaldi MG. Determination of SCH 39304 by megabore capillary gas-liquid chromatography. J Anal Toxicol. 1994 Mar-Apr;18(2):118-21. PubMed PMID: 8207932.

4: Hostetler JS, Catanzaro A, Stevens DA, Graybill JR, Sharkey PK, Larsen RA, Tucker RM, al-Haidary AD, Rinaldi MG, Cloud GA, et al. Treatment of coccidioidomycosis with SCH 39304. J Med Vet Mycol. 1994;32(2):105-14. PubMed PMID: 8064541.

5: Anaissie EJ, Kontoyiannis DP, Vartivarian S, Kantarjian HM, O'Brien S, Giralt SA, Andersson BS, Karl C, Champlin RE, Bodey GP. Effectiveness of an oral triazole for opportunistic mold infections in patients with cancer: experience with SCH 39304. Clin Infect Dis. 1993 Dec;17(6):1022-31. PubMed PMID: 8110925.

6: Brummer E, Hanson LH, Stevens DA. IL-4, IgE, and interferon-gamma production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304). Cell Immunol. 1993 Jul;149(2):258-67. PubMed PMID: 7687197.

7: Parmegiani RM, Loebenberg D, Cacciapuoti A, Antonacci B, Norris C, Menzel F, Moss L, Yarosh-Tomaine T, Hare RS, Miller GH. Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections. J Med Vet Mycol. 1993;31(3):239-48. PubMed PMID: 8360815.

8: Hardin TC, Sharkey PK, Lam YF, Wallace JE, Rinaldi MG, Graybill JR. Pharmacokinetics of SCH-39304 in human immunodeficiency virus-infected patients following chronic oral dosing. Antimicrob Agents Chemother. 1992 Dec;36(12):2790-3. PubMed PMID: 1482146; PubMed Central PMCID: PMC245546.

9: Loebenberg D, Cacciapuoti A, Parmegiani R, Moss EL Jr, Menzel F Jr, Antonacci B, Norris C, Yarosh-Tomaine T, Hare RS, Miller GH. In vitro and in vivo activities of SCH 42427, the active enantiomer of the antifungal agent SCH 39304. Antimicrob Agents Chemother. 1992 Feb;36(2):498-501. PubMed PMID: 1605621; PubMed Central PMCID: PMC188469.

10: Cacciapuoti A, Loebenberg D, Parmegiani R, Antonacci B, Norris C, Moss EL Jr, Menzel F Jr, Yarosh-Tomaine T, Hare RS, Miller GH. Comparison of SCH 39304, fluconazole, and ketoconazole for treatment of systemic infections in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):64-7. PubMed PMID: 1590702; PubMed Central PMCID: PMC189227.

11: Allendoerfer R, Yates RR, Marquis AJ, Loebenberg D, Rinaldi MG, Graybill JR. Comparison of SCH 39304 and its isomers, RR 42427 and SS 42426, for treatment of murine cryptococcal and coccidioidal meningitis. Antimicrob Agents Chemother. 1992 Jan;36(1):217-9. PubMed PMID: 1590692; PubMed Central PMCID: PMC189266.

12: Lee BL, Padula AM, Täuber MG, Chambers HF, Sande MA. Oral SCH 39304 as primary, salvage, and maintenance therapy for cryptococcal meningitis in AIDS. J Acquir Immune Defic Syndr. 1992;5(6):600-4. PubMed PMID: 1588494.

13: Allendoerfer R, Yates RR, Sun SH, Graybill JR. Comparison of amphotericin B lipid complex with amphotericin B and SCH 39304 in the treatment of murine coccidioidal meningitis. J Med Vet Mycol. 1992;30(5):377-84. PubMed PMID: 1469539.

14: Patterson TF, George D, Ingersoll R, Miniter P, Andriole VT. Efficacy of SCH 39304 in treatment of experimental invasive aspergillosis. Antimicrob Agents Chemother. 1991 Oct;35(10):1985-8. PubMed PMID: 1759818; PubMed Central PMCID: PMC245312.

15: Albert MM, Graybill JR, Rinaldi MG. Treatment of murine cryptococcal meningitis with an SCH 39304-amphotericin B combination. Antimicrob Agents Chemother. 1991 Sep;35(9):1721-5. PubMed PMID: 1952837; PubMed Central PMCID: PMC245257.

16: Sugar AM. Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination. Antimicrob Agents Chemother. 1991 Aug;35(8):1669-71. PubMed PMID: 1929339; PubMed Central PMCID: PMC245239.

17: Negroni R, Costa MR, Finquelievich JL, Iovannitti C, Agorio I, Tiraboschi IN, Loebenberg D. Treatment of experimental cryptococcosis with SCH 39304 and fluconazole. Antimicrob Agents Chemother. 1991 Jul;35(7):1460-3. PubMed PMID: 1929309; PubMed Central PMCID: PMC245190.

18: Brummer E, Hanson LH, Stevens DA. SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis. Antimicrob Agents Chemother. 1991 Apr;35(4):788-90. PubMed PMID: 2069391; PubMed Central PMCID: PMC245103.

19: Lunell NO, Pschera H, Zador G, Carlström K. Evaluation of the possible interaction of the antifungal triazole SCH 39304 with oral contraceptives in normal healthy women. Gynecol Obstet Invest. 1991;32(2):91-7. PubMed PMID: 1748330.

20: Walsh TJ, Lee JW, Lecciones J, Kelly P, Peter J, Thomas V, Bacher J, Pizzo PA. SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits. Antimicrob Agents Chemother. 1990 Aug;34(8):1560-4. PubMed PMID: 2221866; PubMed Central PMCID: PMC171873.