Sch 34826

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MedKoo CAT#: 526308

CAS#: 105262-04-2

Description: Sch 34826 is a potent and selective inhibitor of neutral endopeptidase.


Chemical Structure

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Sch 34826
CAS# 105262-04-2

Theoretical Analysis

MedKoo Cat#: 526308
Name: Sch 34826
CAS#: 105262-04-2
Chemical Formula: C27H34N2O7
Exact Mass: 498.24
Molecular Weight: 498.580
Elemental Analysis: C, 65.04; H, 6.87; N, 5.62; O, 22.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Sch 34826; Sch34826; Sch-34826.

IUPAC/Chemical Name: 3-((2S)-2-((1-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-1-oxo-3-phenylpropan-2-yl)amino)-3-phenylpropanamido)propanoic acid

InChi Key: GWLFRMJMKXSMSR-KOENEWCDSA-N

InChi Code: InChI=1S/C27H34N2O7/c1-27(2)35-18-21(36-27)17-34-26(33)23(16-20-11-7-4-8-12-20)29-22(15-19-9-5-3-6-10-19)25(32)28-14-13-24(30)31/h3-12,21-23,29H,13-18H2,1-2H3,(H,28,32)(H,30,31)/t21?,22-,23?/m0/s1

SMILES Code: O=C(O)CCNC([C@H](CC1=CC=CC=C1)NC(CC2=CC=CC=C2)C(OCC3OC(C)(C)OC3)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 498.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kavaliers M, Innes DG. Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826. Pharmacol Biochem Behav. 1993 Dec;46(4):777-80. PubMed PMID: 8309954.

2: Saksida LM, Galea LA, Kavaliers M. Antinociceptive effects of the enkephalinase inhibitor, SCH 34826, in the snail, Cepaea nemoralis. Peptides. 1993 Jul-Aug;14(4):763-5. PubMed PMID: 8234022.

3: Monopoli A, Ongini E, Cigola E, Olivetti G. The neutral endopeptidase inhibitor, SCH 34826, reduces left ventricular hypertrophy in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Sep;20(3):496-504. PubMed PMID: 1279298.

4: Stewart AG, Sheedy W, Thompson JS, Morice AH. Effects of SCH 34826, a neutral endopeptidase inhibitor, on hypoxic pulmonary vascular remodelling. Pulm Pharmacol. 1992 Jun;5(2):111-4. PubMed PMID: 1535251.

5: Jin H, Mathews C, Chen YF, Yang R, Wyss JM, Esunge P, Oparil S. Effects of acute and chronic blockade of neutral endopeptidase with Sch 34826 on NaCl-sensitive hypertension in spontaneously hypertensive rats. Am J Hypertens. 1992 Apr;5(4 Pt 1):210-8. PubMed PMID: 1318053.

6: Richards AM, Crozier IG, Espiner EA, Ikram H, Yandle TG, Kosoglou T, Rallings M, Frampton C. Acute inhibition of endopeptidase 24.11 in essential hypertension: SCH 34826 enhances atrial natriuretic peptide and natriuresis without lowering blood pressure. J Cardiovasc Pharmacol. 1992;20(5):735-41. PubMed PMID: 1280735.

7: Sybertz EJ. SCH 34826: an overview of its profile as a neutral endopeptidase inhibitor and ANF potentiator. Clin Nephrol. 1991 Oct;36(4):187-91. Review. PubMed PMID: 1835684.

8: Burnier M, Ganslmayer M, Perret F, Porchet M, Kosoglou T, Gould A, Nussberger J, Waeber B, Brunner HR. Effects of SCH 34826, an orally active inhibitor of atrial natriuretic peptide degradation, in healthy volunteers. Clin Pharmacol Ther. 1991 Aug;50(2):181-91. PubMed PMID: 1831083.

9: Trampus M, Ongini E, Varani K, Borea PA. The neutral endopeptidase-24.11 inhibitor SCH 34826 does not change opioid binding but reduces D1 dopamine receptors in rat brain. Eur J Pharmacol. 1991 Feb 26;194(1):17-23. PubMed PMID: 1647961.

10: Vemulapalli S, Chiu PJ, Brown A, Griscti K, Sybertz EJ. The blood pressure and renal responses to SCH 34826, a neutral metalloendopeptidase inhibitor, and C-ANF (4-23) in Doca-salt hypertensive rats. Life Sci. 1991;49(5):383-91. Erratum in: Life Sci 1992;50(12):899. PubMed PMID: 1649942.

11: Trampus M, Conti A, Marzanatti M, Monopoli A, Ongini E. Effects of the enkephalinase inhibitor SCH 34826 on the sleep-waking cycle and EEG activity in the rat. Neuropharmacology. 1990 Mar;29(3):199-205. PubMed PMID: 2325830.

12: Sybertz EJ, Chiu PJ, Vemulapalli S, Watkins R, Haslanger MF. Atrial natriuretic factor-potentiating and antihypertensive activity of SCH 34826. An orally active neutral metalloendopeptidase inhibitor. Hypertension. 1990 Feb;15(2):152-61. PubMed PMID: 2154404.

13: Yaksh TL, Chipkin RE. Studies on the effect of SCH-34826 and thiorphan on [Met5]enkephalin levels and release in rat spinal cord. Eur J Pharmacol. 1989 Aug 29;167(3):367-73. PubMed PMID: 2806377.

14: Chipkin RE, Berger JG, Billard W, Iorio LC, Chapman R, Barnett A. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38. PubMed PMID: 3164388.