Sch 29482

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526289

CAS#: 77646-83-4

Description: Sch 29482 is a new penem antibiotic.

Chemical Structure

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Sch 29482
CAS# 77646-83-4
Instruction

Theoretical Analysis

MedKoo Cat#: 526289
Name: Sch 29482
CAS#: 77646-83-4
Chemical Formula: C10H13NO4S2
Exact Mass: 275.03
Molecular Weight: 275.340
Elemental Analysis: C, 43.62; H, 4.76; N, 5.09; O, 23.24; S, 23.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Sch 29482; Sch29482; Sch-29482.

IUPAC/Chemical Name: 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(ethylthio)-6-((1R)-1-hydroxyethyl)-7-oxo-, (5R,6S)-

InChi Key:

InChi Code:

SMILES Code: O=C(C(N12)=C(SCC)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 275.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Méndez R, Negro A, Martín-Villacorta J. High-performance liquid chromatographic methods for the determination of the penems SCH 29482 and FCE 22101 in human serum and urine. J Chromatogr. 1992 Aug 7;579(1):115-21. PubMed PMID: 1447337.

2: Chin NX, Gu JW, Neu HC. Antimicrobial effects of the combination of ceftibuten and an orally absorbed penem SCH 29482. Diagn Microbiol Infect Dis. 1991 Jan-Feb;14(1):79-83. PubMed PMID: 2013213.

3: Schell RF, Francisco M, Bihl JA, LeFrock JL. The activity of ceftazidime compared with those of aztreonam, newer cephalosporins and Sch 29482 against nonfermentative gram-negative bacilli. Chemotherapy. 1985;31(3):181-90. PubMed PMID: 3888543.

4: Baughn RE, Adams C, Musher DM. Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection. Antimicrob Agents Chemother. 1984 Sep;26(3):401-4. PubMed PMID: 6508267; PubMed Central PMCID: PMC176178.

5: Kim H, Oden E, Lin C. High-pressure liquid chromatographic method for determination of Sch 29482 in human serum. Antimicrob Agents Chemother. 1982 Nov;22(5):848-51. PubMed PMID: 7181491; PubMed Central PMCID: PMC185671.

6: Muench RL, Mayhew AL, Hindler JA, Hewitt WL, Young LS. In-vitro activity of Sch 29482--a new penem antibiotic. J Antimicrob Chemother. 1982 Feb;9 Suppl C:71-8. PubMed PMID: 7061378.

7: Hare RS, Miller GH, Naples L, Sabatelli F, Loebenberg D, Waitz JA. Sch 29482, a new penem antibiotic: evaluation of in-vitro activity and effect of test conditions. J Antimicrob Chemother. 1982 Feb;9 Suppl C:7-16. PubMed PMID: 7061377.

8: Weinstein RA, Nathan C, Kabins SA. Comparative in-vivo activity of Sch 29482 and six other extended spectrum cephalosporins. J Antimicrob Chemother. 1982 Feb;9 Suppl C:41-8. PubMed PMID: 7061376.

9: Reeves DS, Bywater MJ, Holt HA. Comparative in-vitro activity of Sch 29482, a new penem antibiotic. J Antimicrob Chemother. 1982 Feb;9 Suppl C:31-40. PubMed PMID: 7061375.

10: Lin C, Kim H, Chung M, Symchowicz S. Pharmacokinetics of Sch 29482 in rats. J Antimicrob Chemother. 1982 Feb;9 Suppl C:233-7. PubMed PMID: 7061373.

11: Loebenberg D, Miller GH, Moss EL Jr, Oden E, Hare RS, Chung M, Waitz JA. Evaluation of the in-vitro activity of Sch 29482. J Antimicrob Chemother. 1982 Feb;9 Suppl C:221-31. PubMed PMID: 7061372.

12: Meyer RD, Pasiecznik KA, Yasui VK, Edelstein PH. Susceptibility of Legionella sp. and nosocomial respiratory tract isolates of Enterobacteriaceae to Sch 29482 and other beta-lactam agents. J Antimicrob Chemother. 1982 Feb;9 Suppl C:199-202. PubMed PMID: 7061371.

13: Yu PK, Washington JA 2nd. Anti-streptococcal activity of Sch 29482--a novel penem antibiotic. J Antimicrob Chemother. 1982 Feb;9 Suppl C:195-8. PubMed PMID: 7061370.

14: Sabath LD, Munyan M, Mach P. Anti-staphylococcal activity of a penem, Sch 29482. J Antimicrob Chemother. 1982 Feb;9 Suppl C:189-94. PubMed PMID: 7061369.

15: Kayser FH, Kuhn I. Sch 29482, laboratory evaluation of a new penem antibiotic. J Antimicrob Chemother. 1982 Feb;9 Suppl C:181-8. PubMed PMID: 7061368.

16: Sutter VL, Kwok YY, Finegold SM. Susceptibility of anaerobic bacteria to Sch 29482. J Antimicrob Chemother. 1982 Feb;9 Suppl C:171-4. PubMed PMID: 7061367.

17: Goldstein FW, Kitzis MD, Andremont AO, Lambert TE, Acar JF. Comparative in-vitro evaluation of Sch 29482, a new beta-lactam antibiotic, on enteropathogenic bacteria. J Antimicrob Chemother. 1982 Feb;9 Suppl C:159-61. PubMed PMID: 7061366.

18: Fass RJ. In-vitro activity of Sch 29482 against bacterial blood isolates. J Antimicrob Chemother. 1982 Feb;9 Suppl C:153-7. PubMed PMID: 7061365.

19: Eliopoulos GM, Gardella A, Moellering RC Jr. In-vitro activity of Sch 29482 in comparison with other oral antibiotics. J Antimicrob Chemother. 1982 Feb;9 Suppl C:143-52. PubMed PMID: 7061364.

20: Counts GW, Turck M. In-vitro activity of Sch 29482--a new oral beta-lactam antibiotic. J Antimicrob Chemother. 1982 Feb;9 Suppl C:137-41. PubMed PMID: 7061363.