SB 211475

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526263

CAS#: 146574-43-8

Description: SB 211475 is a novel antihypertensive agent. SB 211475 is a potent antioxidant. It is a metabolite of carvedilol.


Chemical Structure

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SB 211475
CAS# 146574-43-8

Theoretical Analysis

MedKoo Cat#: 526263
Name: SB 211475
CAS#: 146574-43-8
Chemical Formula: C24H26N2O5
Exact Mass: 422.18
Molecular Weight: 422.480
Elemental Analysis: C, 68.23; H, 6.20; N, 6.63; O, 18.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SB 211475; SB-211475; SB211475.

IUPAC/Chemical Name: 9H-Carbazol-3-ol, 4-(2-hydroxy-3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)-, (+-)-

InChi Key: RWDSIYCVHJZURY-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26N2O5/c1-29-21-8-4-5-9-22(21)30-13-12-25-14-16(27)15-31-24-20(28)11-10-19-23(24)17-6-2-3-7-18(17)26-19/h2-11,16,25-28H,12-15H2,1H3

SMILES Code: OC1=C(OCC(O)CNCCOC2=CC=CC=C2OC)C3=C(C=C1)NC4=C3C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 422.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abreu RM, Santos DJ, Moreno AJ. Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress. J Pharmacol Exp Ther. 2000 Dec;295(3):1022-30. PubMed PMID: 11082437.

2: Gao F, Chen J, Lopez BL, Christopher TA, Gu J, Lysko P, Ruffolo RR Jr, Ohlstein EH, Ma XL, Yue TL. Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. Eur J Pharmacol. 2000 Oct 6;406(1):109-16. PubMed PMID: 11011041.

3: Lysko PG, Lysko KA, Webb CL, Feuerstein G, Mason PE, Walter MF, Mason RP. Neuroprotective activities of carvedilol and a hydroxylated derivative: role of membrane biophysical interactions. Biochem Pharmacol. 1998 Dec 15;56(12):1645-56. PubMed PMID: 9973186.

4: Brunvand H, Liu G, Ma XL, Yue TL, Ruffolo RR Jr, Feuerstein GZ. SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits. Eur J Pharmacol. 1998 Sep 4;356(2-3):193-8. PubMed PMID: 9774249.

5: Christopher TA, Lopez BL, Ma XL, Feuerstein GZ, Ruffolo RR Jr, Yue TL. Effects of a hydroxylated metabolite of the beta-andrenoreceptor antagonist, carvedilol, on post-ischaemic splachnic tissue injury. Br J Pharmacol. 1998 Jan;123(2):292-8. PubMed PMID: 9489618; PubMed Central PMCID: PMC1565158.

6: Yue TL, Mckenna PJ, Lysko PG, Gu JL, Lysko KA, Ruffolo RR Jr, Feuerstein GZ. SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant. Eur J Pharmacol. 1994 Jan 14;251(2-3):237-43. PubMed PMID: 8149979.