Ono-3805 sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530405

CAS#: 119347-91-0 (sodium)

Description: Ono-3805 is a nonsteroidal 5 alpha-reductase inhibitor.

Chemical Structure

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Ono-3805 sodium
CAS# 119347-91-0 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 530405
Name: Ono-3805 sodium
CAS#: 119347-91-0 (sodium)
Chemical Formula: C31H36NNaO5
Exact Mass: 0.00
Molecular Weight: 525.621
Elemental Analysis: C, 70.84; H, 6.90; N, 2.66; Na, 4.37; O, 15.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ono-3805 sodium; Ono-3805; Ono 3805; Ono3805.

IUPAC/Chemical Name: sodium (S)-4-(2-(4-(1-(4-isobutylphenyl)ethoxy)-2,3-dimethylbenzamido)phenoxy)butanoate

InChi Key: MCEJXPXIKHUFRY-BQAIUKQQSA-M

InChi Code: InChI=1S/C31H37NO5.Na/c1-20(2)19-24-12-14-25(15-13-24)23(5)37-28-17-16-26(21(3)22(28)4)31(35)32-27-9-6-7-10-29(27)36-18-8-11-30(33)34;/h6-7,9-10,12-17,20,23H,8,11,18-19H2,1-5H3,(H,32,35)(H,33,34);/q;+1/p-1/t23-;/m0./s1

SMILES Code: O=C([O-])CCCOC1=CC=CC=C1NC(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)C)C(C)=C2C)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 119347-96-5 (Ono-3805 Free) 119347-91-0 (Ono-3805)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 525.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5alpha-reductase inhibitors. Steroids. 2010 Feb;75(2):109-53. doi: 10.1016/j.steroids.2009.10.005. Review. PubMed PMID: 19879888.

2: Igarashi S, Inami H, Hara H, Koutoku H, Oritani H, Mase T. A novel class of inhibitors for human and rat steroid 5alpha-reductases: synthesis and biological evaluation of indoline and aniline derivatives. III. Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1689-97. PubMed PMID: 11086897.

3: Takami H, Nonaka H, Kishibayashi N, Ishii A, Kase H, Kumazawa T. Synthesis of tricyclic compounds as steroid 5alpha-reductase inhibitors. Chem Pharm Bull (Tokyo). 2000 Apr;48(4):552-5. PubMed PMID: 10783077.

4: Takami H, Koshimura H, Kishibayashi N, Ishii A, Nonaka H, Aoyama S, Kase H, Kumazawa T. Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors. J Med Chem. 1996 Dec 20;39(26):5047-52. PubMed PMID: 8978835.

5: Nagamoto A, Noguchi K, Murai T, Kinoshita Y. Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-reductase inhibitor ONO-3805. J Androl. 1994 Nov-Dec;15(6):521-7. PubMed PMID: 7721654.

6: Takahashi O, Imai K, Watanabe K, Nakazawa Y, Nakata S, Kurita M, Saito Y, Kubota H, Yamanaka H. [The effect of sodium-4-[2-(2,3-dimethyl-4-[1-(4- isobutylphenyl)ethoxy]benzolamino)phenoxy] butyrate (ONO-3805) and antiandrogenic agents on the rat accessory sex organs]. Hinyokika Kiyo. 1992 Mar;38(3):305-10. Japanese. PubMed PMID: 1381863.

7: Imai K, Takahashi O, Watanabe K, Nakazawa Y, Nakata S, Yamanaka H. [The effects of antiprostatic agents on the accessory sex organs of rats treated with adrenal androgens]. Hinyokika Kiyo. 1991 Dec;37(12):1669-76. Japanese. PubMed PMID: 1785391.