SB 201823-A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526253

CAS#: 141429-64-3

Description: SB 201823-A is a non-peptide Ca2+ channel antagonist. It is suggested that such novel neuronal Ca2+ channel antagonists may have potential in ameliorating both the pathological and functional consequences of stroke in man.


Chemical Structure

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SB 201823-A
CAS# 141429-64-3

Theoretical Analysis

MedKoo Cat#: 526253
Name: SB 201823-A
CAS#: 141429-64-3
Chemical Formula: C18H27Cl2NO
Exact Mass: 343.15
Molecular Weight: 344.320
Elemental Analysis: C, 62.79; H, 7.90; Cl, 20.59; N, 4.07; O, 4.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SB 201823-A; SB201823A; SB-201823-A.

IUPAC/Chemical Name: 4-(2-(3,4-Dichlorophenoxy)ethyl)-1-pentylpiperidine

InChi Key: DPNXGBOFZKMJSB-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H27Cl2NO.ClH/c1-2-3-4-10-21-11-7-15(8-12-21)9-13-22-16-5-6-17(19)18(20)14-16;/h5-6,14-15H,2-4,7-13H2,1H3;1H

SMILES Code: c1c(c(ccc1OCCC1CCN(CC1)CCCCC)Cl)Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 344.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hicks CA, Ward MA, O'Neill MJ. Neuroprotective effects of the neuronal Ca(2+)
channel blockers, LY042826 and LY393615 in vivo. Eur J Pharmacol. 2000 Nov
24;408(3):241-8. PubMed PMID: 11090640.


2: O'Neill MJ, Bath CP, Dell CP, Hicks CA, Gilmore J, Ambler SJ, Ward MA,
Bleakman D. Effects of Ca2+ and Na+ channel inhibitors in vitro and in global
cerebral ischaemia in vivo. Eur J Pharmacol. 1997 Aug 6;332(2):121-31. PubMed
PMID: 9286613.


3: Barone FC, Lysko PG, Price WJ, Feuerstein G, al-Baracanji KA, Benham CD,
Harrison DC, Harries MH, Bailey SJ, Hunter AJ. SB 201823-A antagonizes calcium
currents in central neurons and reduces the effects of focal ischemia in rats and
mice. Stroke. 1995 Sep;26(9):1683-9; discussion 1689-90. PubMed PMID: 7660415.


4: Benham CD, Brown TH, Cooper DG, Evans ML, Harries MH, Herdon HJ, Meakin JE,
Murkitt KL, Patel SR, Roberts JC, et al. SB 201823-A, a neuronal Ca2+ antagonist
is neuroprotective in two models of cerebral ischaemia. Neuropharmacology. 1993
Nov;32(11):1249-57. PubMed PMID: 8107976.