A939572

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526965

CAS#: 1032229-33-6

Description: A939572 is is a potent and orally bioavailable inhibitor of stearoyl-CoA desaturase1 (SCD1) with IC50 value of 37nM. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.


Price and Availability

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A939572 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526965
Name: A939572
CAS#: 1032229-33-6
Chemical Formula: C20H22ClN3O3
Exact Mass: 387.135
Molecular Weight: 387.864
Elemental Analysis: C, 61.93; H, 5.72; Cl, 9.14; N, 10.83; O, 12.37


Synonym: A939572; A-939572; A 939572.

IUPAC/Chemical Name: (Z)-4-(2-chlorophenoxy)-N-(3-((Z)-hydroxy(methylimino)methyl)phenyl)piperidine-1-carbimidic acid

InChi Key: DPYTYQFYDLYWHZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)

SMILES Code: O/C(N1CCC(OC2=CC=CC=C2Cl)CC1)=N\C3=CC=CC(/C(O)=N/C)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bednarski T, Olichwier A, Opasinska A, Pyrkowska A, Gan AM, Ntambi JM, Dobrzyn P. Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor α. Biochim Biophys Acta. 2016 Oct 15;1861(12 Pt A):2029-2037. doi: 10.1016/j.bbalip.2016.10.005. [Epub ahead of print] PubMed PMID: 27751891.

2: Liu J, Cinar R, Xiong K, Godlewski G, Jourdan T, Lin Y, Ntambi JM, Kunos G. Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18832-7. doi: 10.1073/pnas.1309469110. PubMed PMID: 24191036; PubMed Central PMCID: PMC3839776.

3: von Roemeling CA, Marlow LA, Wei JJ, Cooper SJ, Caulfield TR, Wu K, Tan WW, Tun HW, Copland JA. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368-80. doi: 10.1158/1078-0432.CCR-12-3249. PubMed PMID: 23633458; PubMed Central PMCID: PMC3644999.

4: Paton CM, Ntambi JM. Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1066-75. doi: 10.1152/ajpendo.00388.2010. PubMed PMID: 20923962; PubMed Central PMCID: PMC3006250.