ZK-91296

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526947

CAS#: 83910-34-3

Description: ZK-91296 is a GABA receptor agonist potentially for the treatment of anxiety. ZK 91296 can reduce anxiety in animals at doses well below those causing sedation. ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.


Price and Availability

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ZK-91296 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526947
Name: ZK-91296
CAS#: 83910-34-3
Chemical Formula: C23H22N2O4
Exact Mass: 390.158
Molecular Weight: 390.439
Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39


Synonym: ZK-91296; ZK 91296; ZK91296.

IUPAC/Chemical Name: ethyl 5-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate

SMILES Code: O=C(C1=C(COC)C2=C(C=N1)NC3=C2C(OCC4=CC=CC=C4)=CC=C3)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: De Deyn PP, Macdonald RL. CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. J Pharmacol Exp Ther. 1987 Jul;242(1):48-55. PubMed PMID: 3039114.

2: Sanger DJ, Zivkovic B. Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. Neuropharmacology. 1987 May;26(5):499-505. PubMed PMID: 3037419.

3: Corda MG, Giorgi O, Longoni B, Mereu GP, Biggio G. Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J Neurochem. 1987 May;48(5):1355-8. PubMed PMID: 2881979.

4: Wettstein JG, Spealman RD. Behavioral effects of the beta-carboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone. J Pharmacol Exp Ther. 1987 Feb;240(2):471-5. PubMed PMID: 2879907.

5: Pellow S, File SE. Evidence that the beta-carboline, ZK 91296, can reduce anxiety in animals at doses well below those causing sedation. Brain Res. 1986 Jan 15;363(1):174-7. PubMed PMID: 2868775.

6: Klockgether T, Schwarz M, Turski L, Sontag KH. ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties. Eur J Pharmacol. 1985 Apr 16;110(3):309-15. PubMed PMID: 2861101.

7: Jensen LH, Marescaux C, Vergnes M, Micheletti G, Petersen EN. Antiepileptic action of the beta-carboline ZK 91296 in a genetic petit mal model in rats. Eur J Pharmacol. 1984 Jul 20;102(3-4):521-4. PubMed PMID: 6436039.

8: Petersen EN, Jensen LH, Honoré T, Braestrup C, Kehr W, Stephens DN, Wachtel H, Seidelman D, Schmiechen R. ZK 91296, a partial agonist at benzodiazepine receptors. Psychopharmacology (Berl). 1984;83(3):240-8. PubMed PMID: 6089246.

9: Meldrum BS, Evans MC, Braestrup C. Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel beta-carboline derivative, ZK 91296. Eur J Pharmacol. 1983 Jul 22;91(2-3):255-9. PubMed PMID: 6311579.