Benorilate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329306

CAS#: 5003-48-5

Description: Benorilate, also known as Win-11450, is an ester of aspirin and paracetamol with analgesic, antipyretic, and anti-inflammatory activity used in the treatment of rheumatoid diseases. Benorilate has less severe side effects than aspirin.


Price and Availability

Size
Price

1g
USD 90
10g
USD 450
Size
Price

2g
USD 150
25g
USD 750
Size
Price

5g
USD 250
50g
USD 1250

Benorilate (Win-11450), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329306
Name: Benorilate
CAS#: 5003-48-5
Chemical Formula: C17H15NO5
Exact Mass: 313.095
Molecular Weight: 313.309
Elemental Analysis: C, 65.17; H, 4.83; N, 4.47; O, 25.53


Synonym: Benorilate; Win-11450; Win 11450; Win11450; TO 125; TO-125; TO125; Salipran; Fenasparate

IUPAC/Chemical Name: 4-acetamidophenyl 2-acetoxybenzoate

InChi Key: FEJKLNWAOXSSNR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)

SMILES Code: O=C(OC1=CC=C(NC(C)=O)C=C1)C2=CC=CC=C2OC(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wang CY, Hu XY. Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles. Talanta. 2005 Sep 15;67(3):625-33. doi: 10.1016/j.talanta.2005.03.009. PubMed PMID: 18970216.

2: Chen J, Tu XD. [Studies on formulation and bioavailability of benorilate tablets]. Yao Xue Xue Bao. 1994;29(9):707-12. Chinese. PubMed PMID: 7900541.

3: Jiang JG, Zhang XR, Zhang YH, Song GS. [Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS]. Yao Xue Xue Bao. 2013 Jan;48(1):94-7. Chinese. PubMed PMID: 23600148.

4: Asch L, Ayrolles C, Serratrice G, Simon L. [Clinical study of benorilate. Co-ordinated multi-centre test (author's transl)]. Sem Hop. 1979 Sep 18-25;55(31-32):1395-9. French. PubMed PMID: 41323.

5: Chevalier G, Rohrbach P, Bollet C, Caude M. [Identification and quantitation of impurities from benorilate (Salipran) by high-performance liquid chromatography (author's transl)]. J Chromatogr. 1977 Aug 1;138(1):193-201. French. PubMed PMID: 19488.

6: Lörincz G, Kary K. [Thermographic and histologic studies of the antiinflammatory effect of benorilate by means of the cotton pellet test in the rat (author's transl)]. Arzneimittelforschung. 1975 Oct;25(10):1549-1. German. PubMed PMID: 1041.

7: De Vries J, Jansen JD, Kroese ED, Van Bree L, Van Ginneken CA. Protection against paracetamol-induced glutathione depletion following a paracetamol-acetylsalicylic acid mixture or benorilate in phenobarbital-treated rats. Toxicol Lett. 1981 Dec;9(4):345-7. PubMed PMID: 6120590.

8: Melikhova NI, Klimov IuV. [Clinical evaluation of the effectiveness of benorilate in rheumatoid arthritis in children]. Pediatriia. 1980;(9):52-3. Russian. PubMed PMID: 6107892.

9: de Vries J. Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer? Biochem Pharmacol. 1981 Mar 1;30(5):399-402. PubMed PMID: 6112004.

10: Gao Y, Xu J, Xu J, Huang Y, Shen Y, Liu Z. A rapid and sensitive LC-MS/MS assay for the quantitation of deacetyl mycoepoxydiene in rat plasma with application to preclinical pharmacokinetics studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 1;880(1):1-5. doi: 10.1016/j.jchromb.2011.06.044. PubMed PMID: 22169059.

11: Reiter W. [Long-term toxicity of benorylate]. Z Rheumatol. 1975 Jul-Aug;34(7-8):270-5. German. PubMed PMID: 241174.

12: Marzo A, Quadro G, Treffner E, Ripamonti M, Meroni G, Lucarelli C. High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetylsalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat. Arzneimittelforschung. 1990 Jul;40(7):813-7. PubMed PMID: 1977396.

13: Barasoain I, Rojo JM, Portolés A. "In vivo" effects of acetylsalicylic acid and two ether derived compounds on primary immune response and lymphoblastic transformation. Immunopharmacology. 1980 Dec;2(4):293-300. PubMed PMID: 6109698.

14: Palme G, Koeppe P. [Comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy (author's transl)]. Arzneimittelforschung. 1978;28(3):426-8. German. PubMed PMID: 26360.