Benzydamine Hydrochloride
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MedKoo CAT#: 329302

CAS#: 132-69-4 (HCl)

Description: Benzydamine Hydrochloride, also known as Difflam and AF-864, is a cyclooxygenase inhibitor having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of rheumatic diseases and inflammation of the mouth and throat. Benzydamine Hydrochloride is used to treat painful musculoskeletal and soft-tissue disorders.


Price and Availability

Size
Price

5g
USD 145
Size
Price

Size
Price

Benzydamine Hydrochloride (Difflam, AF-864) purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329302
Name: Benzydamine Hydrochloride
CAS#: 132-69-4 (HCl)
Chemical Formula: C19H24ClN3O
Exact Mass:
Molecular Weight: 345.871
Elemental Analysis: C, 65.98; H, 6.99; Cl, 10.25; N, 12.15; O, 4.63


Synonym: Benzydamine Hydrochloride; AF-864; CAM-2028; AF 864; CAM 2028; AF864; CAM2028; Difflam; Tantum

IUPAC/Chemical Name: 3-((1-benzyl-1H-indazol-3-yl)oxy)-N,N-dimethylpropan-1-amine hydrochloride

InChi Key: HNNIWKQLJSNAEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H

SMILES Code: CN(CCCOC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)C.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#

642-72-8 (Benzydamine )
132-69-4 (Benzydamine Hydrochloride )


References

1: Nimmaanrat S, Chokkijchai K, Chanchayanon T. Efficacy of benzydamine hydrochloride dripping at endotracheal tube cuff for prevention of postoperative sore throat. J Med Assoc Thai. 2013 Oct;96(10):1331-7. PubMed PMID: 24350416.

2: Krzeszowski W, Wilczyński J, Grzesiak M, Nowakowska D. Prenatal sonographic diagnosis of premature constriction of the fetal ductus arteriosus after maternal self-medication with benzydamine hydrochloride: report of 3 cases and review of the literature. J Ultrasound Med. 2015 Mar;34(3):531-5. doi: 10.7863/ultra.34.3.531. Review. PubMed PMID: 25715374.

3: Hung NK, Wu CT, Chan SM, Lu CH, Huang YS, Yeh CC, Lee MS, Cherng CH. Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. Anesth Analg. 2010 Oct;111(4):882-6. doi: 10.1213/ANE.0b013e3181d4854e. PubMed PMID: 20304980.

4: Karavana Hizarcioğlu SY, Sezer B, Güneri P, Veral A, Boyacioğlu H, Ertan G, Epstein JB. Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. Int J Oral Maxillofac Surg. 2011 Sep;40(9):973-8. doi: 10.1016/j.ijom.2011.02.034. PubMed PMID: 21549562.

5: Carlucci G, Iuliani P, Di Federico L. Simultaneous determination of benzydamine hydrochloride and five impurities in an oral collutory as a pharmaceutical formulation by high-performance liquid chromatography. J Chromatogr Sci. 2010 Nov;48(10):854-9. PubMed PMID: 21044418.

6: Chang JE, Min SW, Kim CS, Han SH, Kwon YS, Hwang JY. Effect of prophylactic benzydamine hydrochloride on postoperative sore throat and hoarseness after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled trial. Can J Anaesth. 2015 Oct;62(10):1097-103. doi: 10.1007/s12630-015-0432-x. PubMed PMID: 26149601.

7: Chen CY, Kuo CJ, Lee YW, Lam F, Tam KW. Benzydamine hydrochloride on postoperative sore throat: a meta-analysis of randomized controlled trials. Can J Anaesth. 2014 Mar;61(3):220-8. doi: 10.1007/s12630-013-0080-y. Review. PubMed PMID: 24263969.

8: Cingi C, Songu M, Ural A, Erdogmus N, Yildirim M, Cakli H, Bal C. Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebo-controlled study. J Laryngol Otol. 2011 Jun;125(6):620-5. doi: 10.1017/S0022215111000065. PubMed PMID: 21310101.

9: Mekhemar NA, El-Agwany AS, Radi WK, El-Hady SM. Comparative study between benzydamine hydrochloride gel, lidocaine 5% gel and lidocaine 10% spray on endotracheal tube cuff as regards postoperative sore throat. Braz J Anesthesiol. 2016 May-Jun;66(3):242-8. doi: 10.1016/j.bjane.2014.09.007. PubMed PMID: 27108819.

10: Mekhemar NA, El-Agwany AS, Radi WK, El-Hady SM. [Comparative study between benzydamine hydrochloride gel, lidocaine 5% gel and lidocaine 10% spray on endotracheal tube cuff as regards postoperative sore throat]. Rev Bras Anestesiol. 2016 May-Jun;66(3):242-8. doi: 10.1016/j.bjan.2016.02.011. Portuguese. PubMed PMID: 26993406.

11: Acar YA, Kalkan M, Cetin R, Cevik E, Cınar O. Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol. Case Rep Psychiatry. 2014;2014:290365. doi: 10.1155/2014/290365. PubMed PMID: 25343054; PubMed Central PMCID: PMC4198017.

12: Jayachandran S, Balaji N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care. 2012 Sep;18(3):190-5. doi: 10.4103/0973-1075.105689. PubMed PMID: 23439942; PubMed Central PMCID: PMC3573473.

13: Agarwal A, Nath SS, Goswami D, Gupta D, Dhiraaj S, Singh PK. An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anesth Analg. 2006 Oct;103(4):1001-3. PubMed PMID: 17000820.

14: Kose-Ozkan C, Savaser A, Tas C, Ozkan Y. The development and in vitro evaluation of sustained release tablet formulations of benzydamine hydrochloride and its determination. Comb Chem High Throughput Screen. 2010 Sep;13(8):683-9. PubMed PMID: 20426743.

15: Huang YS, Hung NK, Lee MS, Kuo CP, Yu JC, Huang GS, Cherng CH, Wong CS, Chu CH, Wu CT. The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat. Anesth Analg. 2010 Oct;111(4):887-91. doi: 10.1213/ANE.0b013e3181e6d82a. PubMed PMID: 20581162.