YM-430

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526940

CAS#: 153192-22-4

Description: YM-430, also known as YM-15430; YM-154301; is a dual of β1 adrenergic receptor antagonist and calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent, because of its dual activities. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO. YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina.


Price and Availability

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YM-430 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526940
Name: YM-430
CAS#: 153192-22-4
Chemical Formula: C29H35N3O8
Exact Mass: 553.2424
Molecular Weight: 553.612
Elemental Analysis: C, 62.92; H, 6.37; N, 7.59; O, 23.12


Synonym: YM-15430; YM-154301; YM-15430-1; YM-15430-2; YM-15430-3; YM430; YM-430; YM 430.

IUPAC/Chemical Name: 3-(4-(((S)-2-hydroxy-3-phenoxypropyl)amino)butyl) 5-methyl (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: HBXMSJLNXYLVTA-HOFKKMOUSA-N

InChi Code: InChI=1S/C29H35N3O8/c1-19-25(28(34)38-3)27(21-10-9-11-22(16-21)32(36)37)26(20(2)31-19)29(35)39-15-8-7-14-30-17-23(33)18-40-24-12-5-4-6-13-24/h4-6,9-13,16,23,27,30-31,33H,7-8,14-15,17-18H2,1-3H3/t23-,27-/m0/s1

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OCCCCNC[C@H](O)COC2=CC=CC=C2)=O)[C@H]1C3=CC=CC([N+]([O-])=O)=C3)OC


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sasaki S, Nakagawa M. [Calcium channel blocker for therapy of patients with hypertension]. Nihon Rinsho. 1997 Aug;55(8):2061-6. Review. Japanese. PubMed PMID: 9284424.

2: Shibasaki K, Arai Y, Uchida W, Okazaki T, Asano M, Takenaka T. Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models. Gen Pharmacol. 1997 Oct;29(4):545-50. PubMed PMID: 9352300.

3: Shibasaki K, Uchida W, Takizawa K, Masuda N, Okazaki T, Inagaki O, Asano M, Takenaka T. Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6. PubMed PMID: 9084878.

4: Shibasaki K, Takizawa K, Uchida W, Takenaka T. Hypotensive effects of YM430, a 1,4-dihydropyridine derivative, in spontaneously hypertensive rats and renal hypertensive dogs. Jpn J Pharmacol. 1997 Feb;73(2):113-24. PubMed PMID: 9074945.