ME-3221

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MedKoo CAT#: 526935

CAS#: 139958-16-0

Description: ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan.

Chemical Structure

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ME-3221
CAS# 139958-16-0
Instruction

Theoretical Analysis

MedKoo Cat#: 526935
Name: ME-3221
CAS#: 139958-16-0
Chemical Formula: C22H21N5O2
Exact Mass: 387.17
Molecular Weight: 387.443
Elemental Analysis: C, 68.20; H, 5.46; N, 18.08; O, 8.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ME-3221; ME3221; ME 3221.

IUPAC/Chemical Name: 3-Methoxy-2,6-dimethyl-4-(2'-(1H-tetrazol-5-yl) biphenyl-4-ylmethoxy)pyridine

InChi Key: FTDRSCZZEUAAIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21N5O2/c1-14-12-20(21(28-3)15(2)23-14)29-13-16-8-10-17(11-9-16)18-6-4-5-7-19(18)22-24-26-27-25-22/h4-12H,13H2,1-3H3,(H,24,25,26,27)

SMILES Code: CC1=CC(OCC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)=C(OC)C(C)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 387.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kawano K, Fujishima K, Nagura J, Yasuda S, Shinki, Hachisu M, Konno F. Nonpeptide angiotensin II receptor antagonist recognizes inter-species differences in angiotensin AT1 receptors. Eur J Pharmacol. 1998 Sep 11;357(1):33-9. PubMed PMID: 9788771.

2: Nagura J, Hui C, Yamamoto M, Yasuda S, Abe M, Hachisu M, Konno F. ME3221, a surmountable angiotensin AT1-receptor antagonist, prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1996 May;71(1):39-49. PubMed PMID: 8791170.

3: Nagura J, Yamamoto M, Hui C, Yasuda S, Hachisu M, Konno F. Protective effects of ME3221 on hypertensive complications and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):229-35. PubMed PMID: 8934613.

4: Nagura J, Yasuda S, Fujishima K, Yamamoto M, Hui C, Kawano K, Katano K, Ogino H, Hachisu M, Konno F. Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist. Eur J Pharmacol. 1995 Feb 14;274(1-3):201-11. PubMed PMID: 7768273.

5: Nagura J, Hui C, Yamamoto M, Yasuda S, Abe M, Hachisu M, Konno F. Effect of chronic treatment with ME3221 on blood pressure and mortality in aged stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S363-5. PubMed PMID: 9072429.