Azeloprazole

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MedKoo CAT#: 526902

CAS#: 955095-45-1 (free base)

Description: Azeloprazole, also known as E-3710 and Z-215, is a proton pump inhibitor potentially for treatment of gastroesophageal reflux disease (GERD).

Chemical Structure

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Azeloprazole
CAS# 955095-45-1 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 526902
Name: Azeloprazole
CAS#: 955095-45-1 (free base)
Chemical Formula: C22H27N3O4S
Exact Mass: 429.17
Molecular Weight: 429.535
Elemental Analysis: C, 61.52; H, 6.34; N, 9.78; O, 14.90; S, 7.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 955095-45-1 (free base)   955095-47-3 (sodium)   955095-50-8 (potassium)  

Synonym: E-3710; E 3710; E3710; Z-215; Z 215; Z215; Azeloprazole

IUPAC/Chemical Name: (R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

InChi Key: DWDKHTXMLSZGDL-SSEXGKCCSA-N

InChi Code: InChI=1S/C22H27N3O4S/c1-14-9-23-19(13-30(26)21-24-17-7-5-6-8-18(17)25-21)15(2)20(14)27-10-16-11-28-22(3,4)29-12-16/h5-9,16H,10-13H2,1-4H3,(H,24,25)/t30-/m1/s1

SMILES Code: O=[S@@](C1=NC2=CC=CC=C2N1)CC3=NC=C(C)C(OCC4COC(C)(C)OC4)=C3C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 955095-45-1 (E-3710 free) 955095-47-3 (E-3710 sodium salt)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kodama K, Fujisaki H, Kubota A, Kato H, Hirota K, Kuramochi H, Murota M,
Tabata Y, Ueda M, Harada H, Kawahara T, Shinoda M, Watanabe N, Iida D, Terauchi
H, Yasui S, Miyazawa S, Nagakawa J. E3710, a new proton pump inhibitor, with a
long-lasting inhibitory effect on gastric acid secretion. J Pharmacol Exp Ther.
2010 Aug;334(2):395-401. doi: 10.1124/jpet.110.167783. Epub 2010 May 19. PubMed
PMID: 20484556.