RG 6866

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526121

CAS#: 120602-97-3

Description: RG 6866 is a 5-lipoxygenase inhibitor.


Chemical Structure

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RG 6866
CAS# 120602-97-3

Theoretical Analysis

MedKoo Cat#: 526121
Name: RG 6866
CAS#: 120602-97-3
Chemical Formula: C16H17NO3
Exact Mass: 271.12
Molecular Weight: 271.320
Elemental Analysis: C, 70.83; H, 6.32; N, 5.16; O, 17.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RG 6866; RG6866; RG-6866.

IUPAC/Chemical Name: Benzeneacetamide, N-hydroxy-N-methyl-4-(phenylmethoxy)-

InChi Key: MYMPWMRYZURXNI-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3

SMILES Code: O=C(N(O)C)CC1=CC=C(OCC2=CC=CC=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 271.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gleason MM, Rojas CJ, Learn KS, Perrone MH, Bilder GE. Characterization and inhibition of 15-lipoxygenase in human monocytes: comparison with soybean 15-lipoxygenase. Am J Physiol. 1995 May;268(5 Pt 1):C1301-7. PubMed PMID: 7762624.

2: Folcik VA, Cathcart MK. Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation. J Lipid Res. 1993 Jan;34(1):69-79. PubMed PMID: 8445344.

3: Derian CK, Lewis DF. Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein. Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):49-57. PubMed PMID: 1546066.

4: Snyder DW, Cho HL, Gilmore J. Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. Eur J Pharmacol. 1991 Mar 26;195(2):209-15. PubMed PMID: 1651863.

5: Jolly SR, Ordoukhani A, Movahed A. Effect of neuropeptide Y on isolated rat hearts. Pharmacology. 1991;43(3):121-7. PubMed PMID: 1775516.

6: Carnathan GW, Sweeney DM, Travis JJ, Gordon RJ, Sutherland CA, Jariwala N, Clearfield M, O'Rourke S, Huang FC, Van Inwegen RG. The inhibition of 5-lipoxygenase by RG 6866. Agents Actions. 1989 Nov;28(3-4):204-11. PubMed PMID: 2596372.

7: Jolly SR, Travis J, Van Inwegen RG. Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts. Pharmacology. 1989;38(6):352-62. PubMed PMID: 2813496.