Ralitoline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526083

CAS#: 93738-40-0

Description: Ralitoline is an anticonvulsant. Ralitoline has sodium channel blocking activities. The efficacy of this compound seems to be comparable or even better than that of conventional antiepileptics.


Price and Availability

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Ralitoline is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526083
Name: Ralitoline
CAS#: 93738-40-0
Chemical Formula: C13H13ClN2O2S
Exact Mass: 296.0386
Molecular Weight: 296.77
Elemental Analysis: C, 52.61; H, 4.42; Cl, 11.95; N, 9.44; O, 10.78; S, 10.80


Synonym: Ralitoline; GOE-4942; PD-117818; Ralitolina; CI-946; Ralitolinum.

IUPAC/Chemical Name: (Z)-N-(2-Chloro-6-methylphenyl)-(3-methyl-4-oxothiazolidine-2-ylidene)acetamide

SMILES Code: O=C(NC1=C(C)C=CC=C1Cl)/C=C(N2C)\SCC2=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Dostal LA, Anderson JA. Developmental toxicity study in rats treated with the anticonvulsant, ralitoline. Teratology. 1995 Jan;51(1):11-9. PubMed PMID: 7597653.

2: Fischer W, Bodewei R, Satzinger G. Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Naunyn Schmiedebergs Arch Pharmacol. 1992 Oct;346(4):442-52. PubMed PMID: 1331817.

3: Löscher W, von Hodenberg A, Nolting B, Fassbender CP, Taylor C. Ralitoline: a reevaluation of anticonvulsant profile and determination of "active" plasma concentrations in comparison with prototype antiepileptic drugs in mice. Epilepsia. 1991 Jul-Aug;32(4):560-8. PubMed PMID: 1868813.

4: Rock DM, McLean MJ, Macdonald RL, Catterall WA, Taylor CP. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Epilepsy Res. 1991 Apr;8(3):197-203. PubMed PMID: 1651226.

5: Anhut H, Satzinger G, von Hodenberg A. Ralitoline. Epilepsy Res Suppl. 1991;3:141-5. Review. PubMed PMID: 1777070.

6: Wagner B, Strumpf G, Bartoszyk GD. Similar effects of ralitoline and phenytoin on papillary muscle action potentials: evidence for sodium antagonistic activity. Pharmacol Res Commun. 1987 Sep;19(9):591-6. PubMed PMID: 3432324.