R-547 mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526078

CAS#: 869369-26-6 (mesylate)

Description: R547 Mesylate is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.


Price and Availability

Size
Price

Size
Price

Size
Price

R-547 mesylate, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 526078
Name: R-547 mesylate
CAS#: 869369-26-6 (mesylate)
Chemical Formula: C19H25F2N5O7S2
Exact Mass:
Molecular Weight: 537.55
Elemental Analysis: C, 42.45; H, 4.69; F, 7.07; N, 13.03; O, 20.83; S, 11.93


Related CAS #: 869369-26-6 (mesylate)   741713-40-6 (free base)  

Synonym: R-547 mesylate; RG-547 mesylate; RO-4584820 mesylate.

IUPAC/Chemical Name: 4-Piperidinamine, N-(4-amino-5-(2,3-difluoro-6-methoxybenzoyl)-2-pyrimidinyl)-1-(methylsulfonyl)-, monomethanesulfonate

InChi Key: BUYYGASGVDVCPU-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21F2N5O4S.CH4O3S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28;1-5(2,3)4/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24);1H3,(H,2,3,4)

SMILES Code: O=S(N1CCC(NC2=NC=C(C(C3=C(OC)C=CC(F)=C3F)=O)C(N)=N2)CC1)(C)=O.CS(=O)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Coskun A, Duran S, Apaydin S, Bulut I, Sariyar M. Pregnancy-associated plasma protein-A: evaluation of a new biomarker in renal transplant patients. Transplant Proc. 2007 Dec;39(10):3072-6. PubMed PMID: 18089325.

2: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):427-37. PubMed PMID: 17922073.