ON-013100
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MedKoo CAT#: 406838

CAS#: 865783-95-5

Description: ON-013100 is a cell cycle inhibitor and is potentially useful for the treatment of mantle cell lymphoma.


Price and Availability

Size
Price

1g
USD 3450
Size
Price

2g
USD 5750
Size
Price

5g
Ask price

ON-013100, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406838
Name: ON-013100
CAS#: 865783-95-5
Chemical Formula: C19H22O7S
Exact Mass: 394.1086
Molecular Weight: 394.438
Elemental Analysis: C, 57.86; H, 5.62; O, 28.39; S, 8.13


Synonym: ON-013100; ON 013100; ON013100.

IUPAC/Chemical Name: (E)-5-(((2,4,6-Trimethoxystyryl)sulfonyl)methyl)-2-methoxyphenol

InChi Key: GHPUSRLWNSTQIK-BQYQJAHWSA-N

InChi Code: InChI=1S/C19H22O7S/c1-23-14-10-18(25-3)15(19(11-14)26-4)7-8-27(21,22)12-13-5-6-17(24-2)16(20)9-13/h5-11,20H,12H2,1-4H3/b8-7+

SMILES Code: OC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Cho SY, Cosenza SC, Pallela V, Panda G, Reddy MV, Reddy EP, Roboz J.
Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone
antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal.
2013 Mar 5;75:138-44. doi: 10.1016/j.jpba.2012.11.022. Epub 2012 Nov 23. PubMed
PMID: 23261806.

2: Nuthalapati S, Zhou Q, Guo P, Lv H, Cosenza S, Reddy MV, Reddy EP, Gallo JM.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer
agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor
chemotherapy. Pharm Res. 2012 Sep;29(9):2499-511. doi: 10.1007/s11095-012-0780-y.
Epub 2012 Jun 8. PubMed PMID: 22678771.

3: Park IW, Reddy MV, Reddy EP, Groopman JE. Evaluation of novel cell cycle
inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. Epub
2007 Mar 19. PubMed PMID: 17369860.