CWHM12
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MedKoo CAT#: 526883

CAS#: 1564286-55-0

Description: CWHM12 is a α(v) integrin inhibitor. CWHM 12 can suppress all 5 alpha V integrins. CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method, it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs. Delivering CWHM 12 or a similar small molecule directly into the lungs as an inhalant might offer a way to treat lung fibrosis. harmacological blockade of α(v)-containing integrins by a small molecule (CWHM 12) attenuated both liver and lung fibrosis, including in a therapeutic manner.


Price and Availability

Size
Price

5mg
USD 110
50mg
USD 650
500mg
Ask price
Size
Price

10mg
USD 190
100mg
USD 1150
Size
Price

25mg
USD 350
200mg
USD 1950

CWHM12, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 500mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526883
Name: CWHM12
CAS#: 1564286-55-0
Chemical Formula: C26H32BrN5O6
Exact Mass: 589.1536
Molecular Weight: 590.475
Elemental Analysis: C, 52.89; H, 5.46; Br, 13.53; N, 11.86; O, 16.26


Synonym: CWHM12; CWHM 12; CWHM-12.

IUPAC/Chemical Name: (3S)-3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

InChi Key: YDHAGPCZRFQPOI-NRFANRHFSA-N

InChi Code: InChI=1S/C26H32BrN5O6/c1-26(2,3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28-24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9,20-21,33-34H,10-13H2,1-3H3,(H,28,38)(H,32,35)(H,36,37)(H2,29,30,31)/t21-/m0/s1

SMILES Code: OC1=CC(C(NCC(N[C@@H](CC(O)=O)C2=CC(Br)=CC(C(C)(C)C)=C2)=O)=O)=CC(NC3=NCC(O)CN3)=C1


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH,
Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ,
Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of αv
integrin identifies a core molecular pathway that regulates fibrosis in several
organs. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.
PubMed PMID: 24216753; PubMed Central PMCID: PMC3855865.