Famprofazone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328908

CAS#: 22881-35-2

Description: Famprofazone, also known as Geodowin, is an analgesic used for fever and pain relief. Famprofazone has been demonstrated to be metabolized to methamphetamine and amphetamine following administration. Data shows the famprofazone metabolites amphetamine and methamphetamine to be both d- and l-enantiomers.


Price and Availability

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Famprofazone (Geodowin) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328908
Name: Famprofazone
CAS#: 22881-35-2
Chemical Formula: C24H31N3O
Exact Mass: 377.2467
Molecular Weight: 377.532
Elemental Analysis: C, 76.35; H, 8.28; N, 11.13; O, 4.24


Synonym: Famprofazone; Geodowin; BRN 5768367; BRN-5768367; BRN5768367

IUPAC/Chemical Name: 4-isopropyl-1-methyl-5-((methyl(1-phenylpropan-2-yl)amino)methyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

InChi Key: GNUXVOXXWGNPIV-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H31N3O/c1-18(2)23-22(17-25(4)19(3)16-20-12-8-6-9-13-20)26(5)27(24(23)28)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3

SMILES Code: O=C1N(C2=CC=CC=C2)N(C)C(CN(C)C(C)CC3=CC=CC=C3)=C1C(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Chan KH, Hsu MC, Tseng CY, Chu WL. Famprofazone use can be misinterpreted as methamphetamine abuse. J Anal Toxicol. 2010 Jul-Aug;34(6):347-53. PubMed PMID: 20663288.

2: Oh ES, Hong SK, Kang GI. Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man. Xenobiotica. 1992 Mar;22(3):377-84. PubMed PMID: 1496827.

3: Greenhill B, Valtier S, Cody JT. Metabolic profile of amphetamine and methamphetamine following administration of the drug famprofazone. J Anal Toxicol. 2003 Oct;27(7):479-84. PubMed PMID: 14607003.

4: Shin HS. Stereoselective metabolism of famprofazone in humans: N-dealkylation and beta- and p-hydroxylation. Chirality. 1997;9(1):52-8. PubMed PMID: 9094203.

5: Cody JT. Enantiomeric composition of amphetamine and methamphetamine derived from the precursor compound famprofazone. Forensic Sci Int. 1996 Jul 12;80(3):189-99. PubMed PMID: 8682419.

6: Tseng YL, Lin CT, Wang SM, Liu RH. Famprofazone as the source of methamphetamine and amphetamine in urine specimen collected during sport competition. J Forensic Sci. 2007 Mar;52(2):479-86. PubMed PMID: 17316255.

7: Rodriguez AT, Valtier S, Cody JT. Metabolic profile of famprofazone following multidose administration. J Anal Toxicol. 2004 Sep;28(6):432-8. PubMed PMID: 15516292.

8: Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H. Identification of new urinary metabolites of famprofazone in humans. J Anal Toxicol. 1998 Jan-Feb;22(1):55-60. PubMed PMID: 9491970.

9: Neugebauer M, Khedr A, el-Rabbat N, el-Kommos M, Saleh G. Stereoselective metabolic study of famprofazone. Biomed Chromatogr. 1997 Nov-Dec;11(6):356-61. PubMed PMID: 9413615.

10: Shin HS, Park JS, Park PB, Yun SJ. Detection and identification of famprofazone and its metabolite in human urine. J Chromatogr B Biomed Appl. 1994 Nov 18;661(2):255-61. PubMed PMID: 7894665.

11: Yoo Y, Chung H, Choi H. Urinary methamphetamine concentration following famprofazone administration. J Anal Toxicol. 1994 Sep;18(5):265-8. PubMed PMID: 7990444.

12: Musshoff F, Kraemer T. Identification of famprofazone ingestion. Int J Legal Med. 1998;111(6):305-8. PubMed PMID: 9826089.

13: Neugebauer M. Some new urinary metabolites of famprofazone and morazone in man. J Pharm Biomed Anal. 1984;2(1):53-60. PubMed PMID: 16867765.

14: Lee SC, Kim YG, Ryu DM, Lee BS. [Clinical evaluation of Famprofazone (Apagan, liquid type) in oral surgery]. Taehan Chikkwa Uisa Hyophoe Chi. 1987 Aug;25(8):769-73. Korean. PubMed PMID: 3506950.

15: Musshoff F. Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine. Drug Metab Rev. 2000 Feb;32(1):15-44. Review. PubMed PMID: 10711406.

16: Cody JD. Metabolic Precursors to Amphetamine and Methamphetamine. Forensic Sci Rev. 1993 Dec;5(2):109-27. Review. PubMed PMID: 26270078.

17: Cody JT. Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results. J Occup Environ Med. 2002 May;44(5):435-50. Review. PubMed PMID: 12024689.

18: Kraemer T, Maurer HH. Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Ther Drug Monit. 2002 Apr;24(2):277-89. Review. PubMed PMID: 11897973.