Halothane
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328805

CAS#: 151-67-7

Description: Halothane, also known as Fluothane, is a CYP3A4 substrate used for anesthesia.


Price and Availability

Size
Price

125mg
USD 250
Size
Price

250mg
USD 430
Size
Price

Halothane (Fluothane), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328805
Name: Halothane
CAS#: 151-67-7
Chemical Formula: C2HBrClF3
Exact Mass: 195.8902
Molecular Weight: 197.3792
Elemental Analysis: C, 12.17; H, 0.51; Br, 40.48; Cl, 17.96; F, 28.88


Synonym: Halothane; Fluothane; BRN 1736947; BRN-1736947; BRN1736947;

IUPAC/Chemical Name: 2-bromo-2-chloro-1,1,1-trifluoroethane

InChi Key: BCQZXOMGPXTTIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

SMILES Code: FC(F)(F)C(Br)Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: MacDonald BA, Chakravarthy KV, Davidson BA, Mullan BA, Alluri R, Hakansson AP, Knight PR. Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model. Anesthesiology. 2015 Sep;123(3):590-602. doi: 10.1097/ALN.0000000000000766. PubMed PMID: 26120770; PubMed Central PMCID: PMC4678100.

2: Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR. Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment. Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764. Epub 2015 Mar 25. PubMed PMID: 25712247.

3: Li F, Liao D, Liu J, Xiao L, Guo J, Yi M, Zhou C. Emulsified halothane produces long-term epidural anesthetic effect: a study in rabbits. Int J Clin Exp Pathol. 2015 May 1;8(5):4573-80. eCollection 2015. PubMed PMID: 26191147; PubMed Central PMCID: PMC4503019.

4: Wang J, Yang X, Xiao H, Kong J, Bing M. Determination of the mechanism of action of repetitive halothane exposure on rat brain tissues using a combined method of microarray gene expression profiling and bioinformatics analysis. Mol Med Rep. 2015 Dec;12(6):8071-6. doi: 10.3892/mmr.2015.4462. Epub 2015 Oct 21. PubMed PMID: 26497548.

5: Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F. Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death. Anesthesiology. 2015 Sep;123(3):603-17. doi: 10.1097/ALN.0000000000000748. PubMed PMID: 26132720; PubMed Central PMCID: PMC4543432.

6: Nomura H, Nakamura Y, Cao X, Honda A, Katagi J, Ohara H, Izumi-Nakaseko H, Satoh Y, Ando K, Sugiyama A. Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs. Eur J Pharmacol. 2015 Aug 15;761:217-25. doi: 10.1016/j.ejphar.2015.06.012. Epub 2015 Jun 11. PubMed PMID: 26073024.

7: Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A. Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs. J Toxicol Sci. 2016 Feb;41(1):115-22. doi: 10.2131/jts.41.115. PubMed PMID: 26763398.

8: da Silva FF, Duflot D, Hoffmann SV, Jones NC, Rodrigues FN, Ferreira-Rodrigues AM, de Souza GG, Mason NJ, Eden S, Limão-Vieira P. Electronic State Spectroscopy of Halothane As Studied by ab Initio Calculations, Vacuum Ultraviolet Synchrotron Radiation, and Electron Scattering Methods. J Phys Chem A. 2015 Aug 6;119(31):8503-11. doi: 10.1021/acs.jpca.5b05308. Epub 2015 Jul 28. PubMed PMID: 26171941.

9: Bezerra FJ, Brown M, Alarcon W, Karki K, Knight RA, Keenan KA, Nagaraja TN. Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. Neurol Res. 2014 Sep;36(9):847-50. doi: 10.1179/1743132814Y.0000000341. Epub 2014 Mar 7. PubMed PMID: 24601723.

10: Warrener T, Tindall M, Stanley D. The return of halothane anaesthesia? Eur J Anaesthesiol. 2014 Dec;31(12):709-10. doi: 10.1097/EJA.0000000000000069. PubMed PMID: 24809479.