Indisetron Dihydrochloride

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MedKoo CAT#: 328716

CAS#: 160472-97-9 (2HCl)

Description: Indisetron Dihydrochloride, also known as N-3389T and Sinseron, is a 5-HT(3) and 5-HT(4) receptor antagonist. Indisetron reduces 2-methyl-5-serotonin (HT)-induced bradycardia. The 5-HT3 antagonistic activity is over 20 times more than that of granisetron or ondansetron, indicating the excellent anti-emetic activity against anticancer drug induced vomiting.


Chemical Structure

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Indisetron Dihydrochloride
CAS# 160472-97-9 (2HCl)

Theoretical Analysis

MedKoo Cat#: 328716
Name: Indisetron Dihydrochloride
CAS#: 160472-97-9 (2HCl)
Chemical Formula: C17H25Cl2N5O
Exact Mass: 0.00
Molecular Weight: 386.321
Elemental Analysis: C, 52.85; H, 6.52; Cl, 18.35; N, 18.13; O, 4.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 160472-97-9 (2HCl)   141549-75-9 (free base),  

Synonym: Indisetron Dihydrochloride; N-3389T; N 3389T; N3389T; Sinseron

IUPAC/Chemical Name: N-(3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-yl)-1H-indazole-3-carboxamide dihydrochloride

InChi Key: KOYCUQMOCJHRJC-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H23N5O.2ClH/c1-21-9-12-7-11(8-13(10-21)22(12)2)18-17(23)16-14-5-3-4-6-15(14)19-20-16;;/h3-6,11-13H,7-10H2,1-2H3,(H,18,23)(H,19,20);2*1H

SMILES Code: O=C(C1=NNC2=C1C=CC=C2)NC3CC4CN(C)CC(N4C)C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 141549-75-9(Indisetron ) 160472-97-9(Indisetron 2HCl)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tsukagoshi S; Tokyo Cooperative Oncology Group. [Introduction of novel anti-emetic agent, indisetron hydrochloride, developed recently in Japan]. Gan To Kagaku Ryoho. 2005 Apr;32(4):567-73. Review. Japanese. PubMed PMID: 15853230.

2: Iritani E, Isono K, Izumo T, Takeda N, Kanemura T, Tamaoki J, Nagai A. [The efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting for lung cancer]. Gan To Kagaku Ryoho. 2009 Sep;36(9):1489-92. Japanese. PubMed PMID: 19755818.

3: Kanbe M, Osada M. [CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report]. Gan To Kagaku Ryoho. 2005 Dec;32(13):2145-7. Japanese. PubMed PMID: 16352947.

4: Nakatsumi H, Komatsu Y, Yuki S, Sogabe S, Tateyama M, Muto S, Kudo M, Kato K, Miyagishima T, Uebayashi M, Meguro T, Oba K, Asaka M. Optimal dose period for indisetron tablets for preventing chemotherapy-induced nausea and vomiting with modified FOLFOX6: a randomized pilot study. Chemotherapy. 2012;58(6):439-44. doi: 10.1159/000345920. Epub 2013 Jan 29. PubMed PMID: 23364217.

5: Sharma A, Sonah H, Deshmukh RK, Gupta NK, Singh NK, Sharma TR. Analysis of genetic diversity in earthworms using DNA markers. Zoolog Sci. 2011 Jan;28(1):25-31. doi: 10.2108/zsj.28.25. PubMed PMID: 21186943.